ArticlePloS one2011
Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity.Cell adhesion & migration · 2023Article
- Actin protrusions push at apical junctions to maintain E-cadherin adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Adherens Junctions: Guardians of Cortical Development.Frontiers in cell and developmental biology · 2020Review
- Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II.Frontiers in cell and developmental biology · 2019Review
- Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.Nature communications · 2017Article
- Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions.PLoS computational biology · 2017Article
- ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.Molecular biology of the cell · 2017Article
- Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension.Nature communications · 2016Article
- Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.Nature cell biology · 2015Article
- An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.Molecular biology of the cell · 2015Article
- Article
- Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.Cell cycle (Georgetown, Tex.) · 2015Article
- Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.The Journal of biological chemistry · 2014Article
- Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia.Nature cell biology · 2014Article
- A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.Molecular biology of the cell · 2012Article
- A bigger picture: classical cadherins and the dynamic actin cytoskeleton.Nature reviews. Molecular cell biology · 2012Review
- Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.Nature cell biology · 2012Article
- Myosins in cell junctions.BioarchitectureReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zonula adherens (ZA) of epithelial cells is a site of cell-cell adhesion where cellular forces are exerted and resisted. Increasing evidence indicates that E-cadherin adhesion molecules at the ZA serve to sense force applied on the junctions and coordinate cytoskeletal responses to those forces. Efforts to understand the role that cadherins play in mechanotransduction have been limited by the lack of assays to measure the impact of forces on the ZA. In this study we used 4D imaging of GFP-tagged E-cadherin to analyse the movement of the ZA. Junctions in confluent epithelial monolayers displayed prominent movements oriented orthogonal (perpendicular) to the ZA itself. Two components were identified in these movements: a relatively slow unidirectional (translational) component that could be readily fitted by least-squares regression analysis, upon which were superimposed more rapid oscillatory movements. Myosin IIB was a dominant factor responsible for driving the unilateral translational movements. In contrast, frequency spectrum analysis revealed that depletion of Myosin IIA increased the power of the oscillatory movements. This implies that Myosin IIA may serve to dampen oscillatory movements of the ZA. This extends our recent analysis of Myosin II at the ZA to demonstrate that Myosin IIA and Myosin IIB make distinct contributions to junctional movement at the ZA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.