ArticlePloS one2011
Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peptide Designs for Use in Caries Management: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Antimicrobial and Cytotoxic Activities of Biogenic Nanoparticles Produced by Cyanobacteria.Chembiochem : a European journal of chemical biology · 2026Review
- Tandem solubility enhancing tags enable the heterologous expression andFrontiers in microbiology · 2026Article
- Towards the control of biofilm formation in Anabaena (Nostoc) sp. PCC7120: novel insights into the genes involved and their regulation.The New phytologist · 2025Article
- Microbial Rumen proteome analysis suggests Firmicutes and Bacteroidetes as key producers of lignocellulolytic enzymes and carbohydrate-binding modules.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Diversity and specificity of molecular functions in cyanobacterial symbionts.Scientific reports · 2024Article
- Revisiting the Multifaceted Roles of Bacteriocins : The Multifaceted Roles of Bacteriocins.Microbial ecology · 2024Review
- Uncovering the diversity and distribution of biosynthetic gene clusters of prochlorosins and other putative RiPPs in marineMicrobiology spectrum · 2024Article
- Characterization of the Novel Leaderless Bacteriocin, Bawcin, fromInternational journal of molecular sciences · 2023Article
- Exploring the Relationship between Biosynthetic Gene Clusters and Constitutive Production of Mycosporine-like Amino Acids in Brazilian Cyanobacteria.Molecules (Basel, Switzerland) · 2023Article
- Invert emulsions alleviate biotic interactions in bacterial mixed culture.Microbial cell factories · 2023Article
- Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development.Microbiology (Reading, England) · 2022Article
- Ubericin K, a New Pore-Forming Bacteriocin Targeting mannose-PTS.Microbiology spectrum · 2021Article
- Article
- Anabaenopeptins: What We Know So Far.Toxins · 2021Review
- Enterocin Cross-Resistance Mediated by ABC Transport Systems.Microorganisms · 2021Article
- Genome Reduction and Secondary Metabolism of the Marine Sponge-Associated CyanobacteriumMarine drugs · 2021Article
- Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.Marine drugs · 2021Review
- Current Knowledge on Microviridin from Cyanobacteria.Marine drugs · 2021Review
- Reconstructing Draft Genomes Using Genome Resolved Metagenomics Reveal Arsenic Metabolizing Genes and Secondary Metabolites in Fresh Water Lake in Eastern India.Bioinformatics and biology insights · 2021Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanobacteria are a rich source of natural products with interesting biological activities. Many of these are peptides and the end products of a non-ribosomal pathway. However, several cyanobacterial peptide classes were recently shown to be produced through the proteolytic cleavage and post-translational modification of short precursor peptides. A new class of bacteriocins produced through the proteolytic cleavage and heterocyclization of precursor proteins was recently identified from marine cyanobacteria. Here we show the widespread occurrence of bacteriocin gene clusters in cyanobacteria through comparative analysis of 58 cyanobacterial genomes. A total of 145 bacteriocin gene clusters were discovered through genome mining. These clusters encoded 290 putative bacteriocin precursors. They ranged in length from 28 to 164 amino acids with very little sequence conservation of the core peptide. The gene clusters could be classified into seven groups according to their gene organization and domain composition. This classification is supported by phylogenetic analysis, which further indicated independent evolutionary trajectories of gene clusters in different groups. Our data suggests that cyanobacteria are a prolific source of low-molecular weight post-translationally modified peptides.
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