ArticleBiomicrofluidics2011
Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation.
Article in Biomicrofluidics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Recent Progress of In Vitro 3D Culture of Male Germ Stem Cells.Journal of functional biomaterials · 2023Review
- Review
- Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neuronsiScience · 2022Article
- Recent advances in microarray 3D bioprinting for high-throughput spheroid and tissue culture and analysis.Essays in biochemistry · 2021Review
- 3D cell aggregate printing technology and its applications.Essays in biochemistry · 2021Review
- Cutting and Bonding ParafilmCellular and molecular bioengineering · 2021Article
- Engineered Microsystems for Spheroid and Organoid Studies.Advanced healthcare materials · 2021Review
- Article
- Effect of cellular mass on chondrogenic differentiation during embryoid body formation.Molecular medicine reports · 2018Article
- Cardiomyocytes Derived from HumanScientific reports · 2018Article
- 3D Bioprinting Stem Cell Derived Tissues.Cellular and molecular bioengineering · 2018Review
- Generating Chondromimetic Mesenchymal Stem Cell Spheroids by Regulating Media Composition and Surface Coating.Cellular and molecular bioengineering · 2018Article
- Print Me an Organ? Ethical and Regulatory Issues Emerging from 3D Bioprinting in Medicine.Science and engineering ethics · 2018Article
- Bioprinting of skin constructs for wound healing.Burns & trauma · 2018Review
- 3-D Microwell Array System for Culturing Virus Infected Tumor Cells.Scientific reports · 2016Article
- High-Throughput Non-Contact Vitrification of Cell-Laden Droplets Based on Cell Printing.Scientific reports · 2015Article
- Engineering cancer microenvironments forMaterials today (Kidlington, England) · 2015Article
- Engineering anisotropic biomimetic fibrocartilage microenvironment by bioprinting mesenchymal stem cells in nanoliter gel droplets.Molecular pharmaceutics · 2014Article
- Generating size-controlled embryoid bodies using laser direct-write.Biofabrication · 2014Article
- Naive-like conversion overcomes the limited differentiation capacity of induced pluripotent stem cells.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Embryonic stem cells (ESCs) are pluripotent with multilineage potential to differentiate into virtually all cell types in the organism and thus hold a great promise for cell therapy and regenerative medicine. In vitro differentiation of ESCs starts with a phase known as embryoid body (EB) formation. EB mimics the early stages of embryogenesis and plays an essential role in ESC differentiation in vitro. EB uniformity and size are critical parameters that directly influence the phenotype expression of ESCs. Various methods have been developed to form EBs, which involve natural aggregation of cells. However, challenges persist to form EBs with controlled size, shape, and uniformity in a reproducible manner. The current hanging-drop methods are labor intensive and time consuming. In this study, we report an approach to form controllable, uniform-sized EBs by integrating bioprinting technologies with the existing hanging-drop method. The approach presented here is simple, robust, and rapid. We present significantly enhanced EB size uniformity compared to the conventional manual hanging-drop method.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.