ArticleEvidence-based complementary and alternative medicine : eCAM2011
Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Comparative Pharmacological Profiling of Psychotherapeutic Drugs Reveals a Functional Taxonomy Based on Direct Inhibition of Smooth Muscle Excitability.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Comparative study amongSaudi journal of biological sciences · 2022Article
- The Uterotonic Screening of the Root Extract ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- In-VITRo effect of Ficus deltoidea on the contraction of isolated rat's uteri is mediated via multiple receptors binding and is dependent on extracellular calcium.BMC complementary and alternative medicine · 2013Article
- Effects of Ficus asperifolia on normal rat estrus cyclicity.Asian Pacific journal of tropical biomedicine · 2013Article
- Anticancer and antimicrobial activities of some antioxidant-rich cameroonian medicinal plants.PloS one · 2013Article
- Antispasmodic and Antidiarrheal Activities of Valeriana hardwickii Wall. Rhizome Are Putatively Mediated through Calcium Channel Blockade.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- An Overview of Phytochemical and Biological Activities:Journal of pharmacy & bioallied sciencesReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to determine the uterotonic activities of Ficus asperifolia and investigate its mechanism. The effects of aqueous and methanol extracts of the dried fruits of F. asperifolia (0.05-1.60 mg mL(-1)) were evaluated on estrogenized isolated rat uterus in the presence and absence of atropine (1.73-55.27 nM), pyrilamine maleate (1.25 × 10(-3) to 40 × 10(-3) M), indomethacin (0.06 × 10(-5) to 2.00 × 10(-5) M) or hexamethonium (0.66 × 10(-4) to 21.43 × 10(-4) M). Aqueous (EC(50), 0.36 mg mL(-1)) and methanol (EC(50), 0.22 mg mL(-1)) extracts as well as oxytocin (EC(50), 0.02 nM), acetylcholine (EC(50), 7.87 nM) and histamine (EC(50), 0.76 nM) evoked concentration-dependent contractions of the uterus. Atropine, pyrilamine maleate and indomethacin concentration dependently blocked the response of the uterus to acetylcholine (IC(50), 4.82 nM), histamine (IC(50), 2.49 nM) and oxytocin (IC(50), 0.07 nM), respectively, and to aqueous extract. Hexamethonium produced graded decreases in oxytocin-induced uterine contractions (IC(50), 0.37 μM), but did not prevent the contractile effects of the aqueous extract (IC(50), 9.88 μM). These results suggest that F. asperifolia-induced uterotonic effect is related to the release of prostaglandins and contraction of the myometrial cells through muscarinic, oxytocic and H(1) histamine receptors. These data further give added value to the ethnic use of F. asperifolia for its abortificient and contraceptive properties.
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Registered trials
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