ArticleWorld journal of gastroenterology2011
Association of upper gastrointestinal symptoms with functional and clinical charateristics in elderly.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Clinical, Endoscopic and Histologic Differences in Gastric Mucosa Between Younger and Older Adults: An Observational Study on the Aging Stomach.Medical sciences (Basel, Switzerland) · 2025Observational
- Article
- The Aging Stomach: Clinical Implications ofInternational journal of molecular sciences · 2024Review
- Helicobacter pylori Eradication Treatment in Older Patients.Drugs & aging · 2024Review
- Low Frequency of Upper Gastrointestinal Bleeding Despite Non-Steroidal Anti-Inflammatory Drugs and Corticosteroids in Patients with Rheumatoid Arthritis.Current rheumatology reviews · 2024Article
- Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review.Journal of personalized medicine · 2023Review
- Focusing onFrontiers in cellular and infection microbiology · 2023Review
- Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date.Clinical interventions in aging · 2022Review
- The gut microbiota and nervous system: Age-defined and age-defying.Seminars in cell & developmental biology · 2021Article
- Endoscopic Findings of Gastro-Esophageal Reflux Disease in Elderly and Younger Age Groups.Frontiers in medicine · 2021Article
- Review
- Helicobacter pylori infection in older people.World journal of gastroenterology · 2014Review
- Patient Perspective on Adherence to Reflux Lifestyle Modifications: A Qualitative Study.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the prevalence of upper gastrointestinal symptoms and their association with clinical and functional characteristics in elderly outpatients.
methodsThe study involved 3238 outpatients ≥ 60 years consecutively enrolled by 107 general practitioners. Information on social, behavioral and demographic characteristics, function in the activities of daily living (ADL), co-morbidities and drug use were collected by a structured interview. Upper gastrointestinal symptom data were collected by the 15-items upper gastro-intestinal symptom questionnaire for the elderly, a validated diagnostic tool which includes the following five symptom clusters: (1) abdominal pain syndrome; (2) reflux syndrome; (3) indigestion syndrome; (4) bleeding; and (5) non-specific symptoms. Presence and severity of gastrointestinal symptoms were analyzed through a logistic regression model.
results3100 subjects were included in the final analysis. The overall prevalence of upper gastrointestinal symptoms was 43.0%, i.e. cluster (1) 13.9%, (2) 21.9%, (3) 30.2%, (4) 1.2%, and (5) 4.5%. Upper gastrointestinal symptoms were more frequently reported by females (P < 0.0001), with high number of co-morbidities (P < 0.0001), who were taking higher number of drugs (P < 0.0001) and needed assistance in the ADL. Logistic regression analysis demonstrated that female sex (OR = 1.39, 95% CI: 1.17-1.64), disability in the ADL (OR = 1.47, 95% CI: 1.12-1.93), smoking habit (OR = 1.29, 95% CI: 1.00-1.65), and body mass index (OR = 1.06, 95% CI: 1.04-1.08), as well as the presence of upper (OR = 3.01, 95% CI: 2.52-3.60) and lower gastroenterological diseases (OR = 2.25, 95%CI: 1.70-2.97), psychiatric (OR = 1.60, 95% CI: 1.28-2.01) and respiratory diseases (OR = 1.25, 95% CI: 1.01-1.54) were significantly associated with the presence of upper gastrointestinal symptoms.
conclusionFunctional and clinical characteristics are associated with upper gastrointestinal symptoms. A multidimensional comprehensive evaluation may be useful when approaching upper gastrointestinal symptoms in older subjects.
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