ArticleObesity (Silver Spring, Md.)2012
Common genetic variants and central adiposity among Asian-Indians.
Article in Obesity (Silver Spring, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Effects of Active Learning Education on Arterial Stiffness of Older Adults with Low Health Literacy: A Randomized Controlled Trial.Journal of atherosclerosis and thrombosis · 2021Trial
- Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.Journal of personalized medicine · 2023Review
- Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review.Frontiers in endocrinology · 2023Article
- Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort.PloS one · 2022Article
- Genomics of body fat distribution.Journal of genetics · 2021Review
- Genetics of Obesity in East Asians.Frontiers in genetics · 2020Review
- Assessment of FTO Gene Polymorphism and its Association with Type 2 Diabetes Mellitus in North Indian Populations.Indian journal of clinical biochemistry : IJCB · 2019Article
- South Asian Cardiovascular Disease & Cancer Risk: Genetics & Pathophysiology.Journal of community health · 2018Review
- Genetics of obesity and its measures in India.Journal of genetics · 2018Review
- The interaction of fat mass and obesity associated gene polymorphisms and dietary fiber intake in relation to obesity phenotypes.Scientific reports · 2017Article
- Update on the State of the Science for Analytical Methods for Gene-Environment Interactions.American journal of epidemiology · 2017Article
- Lessons Learned From Past Gene-Environment Interaction Successes.American journal of epidemiology · 2017Review
- Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes.Nutrients · 2017Article
- The importance of gene-environment interactions in human obesity.Clinical science (London, England : 1979) · 2016Review
- Finding the missing gene-environment interactions.European journal of epidemiology · 2015Article
- Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity.Human genetics · 2015Review
- Indicators of the metabolic syndrome in obese adolescents.Archives of medical science : AMS · 2015Article
- Role of FTO in Adipocyte Development and Function: Recent Insights.International journal of endocrinology · 2015Review
- The bigger picture of FTO: the first GWAS-identified obesity gene.Nature reviews. Endocrinology · 2014Review
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
Recent studies have identified common genetic variants that are unequivocally associated with central adiposity, BMI, and/or fasting plasma glucose among individuals of European descent. Our objective was to evaluate these associations in a population of Asian-Indians. We examined 16 single-nucleotide polymorphisms (SNPs) from loci previously linked to waist circumference, BMI, or fasting glucose in 1,129 Asian-Indians from New Delhi and Trivandrum. Trained medical staff measured waist circumference, height, and weight. Fasting plasma glucose was measured from collected blood specimens. Genotype-phenotype associations were evaluated using linear regression, with adjustments for age, gender, religion, and study region. For gene-environment interaction tests, total physical activity (PA) during the past 7 days was assessed by the International Physical Activity Questionnaire (IPAQ). The T allele at the FTO rs3751812 locus was associated with increased waist circumference (per allele effect of +1.58 cm, P(trend) = 0.0015) after Bonferroni adjustment for multiple testing (P(adj) = 0.04). We also found a nominally statistically significant FTO-PA interaction (P(interaction) = 0.008). Among participants with <81 metabolic equivalent (MET)-h/wk of PA, the rs3751812 variant was associated with increased waist size (+2.68 cm; 95% confidence interval (CI) = 1.24, 4.12), but not among those with 212+ MET-h/wk (-1.79 cm; 95% CI = -4.17, 0.58). No other variant had statistically significant associations, although statistical power was modest. In conclusion, we confirmed that an FTO variant associated with central adiposity in European populations is associated with central adiposity among Asian-Indians and corroborated prior reports indicating that high PA attenuates FTO-related genetic susceptibility to adiposity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.