ArticleSchizophrenia bulletin2013
The effect of neurogranin on neural correlates of episodic memory encoding and retrieval.
Article in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis.Medicine · 2019Pooled it
- Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Molecular psychiatry · 2014Pooled it
- Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.PloS one · 2013Trial
- Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Proteomic discovery in sickle cell disease: Elevated neurogranin levels in children with sickle cell disease.Proteomics. Clinical applications · 2021Article
- The Effect of Comorbid Attention-Deficit/Hyperactivity Disorder Symptoms on Face Memory in Children with Autism Spectrum Disorder: Insights from Transdiagnostic Profiles.Brain sciences · 2021Article
- Neurobiology of the major psychoses: a translational perspective on brain structure and function-the FOR2107 consortium.European archives of psychiatry and clinical neuroscience · 2019Article
- Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia.BMC psychiatry · 2019Article
- Imaging Genetics Towards a Refined Diagnosis of Schizophrenia.Frontiers in psychiatry · 2019Review
- Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe.Genome medicine · 2016Article
- Developmental regulation of human cortex transcription and its clinical relevance at single base resolution.Nature neuroscience · 2015Article
- Altered neural function during episodic memory encoding and retrieval in major depression.Human brain mapping · 2014Article
- A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval.European archives of psychiatry and clinical neuroscience · 2014Article
- Article
- Memory deficits in schizophrenia: a selective review of functional magnetic resonance imaging (FMRI) studies.Behavioral sciences (Basel, Switzerland) · 2013Review
- The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function.PloS one · 2013Article
- Neuroimaging and genetics: exploring, searching, and finding.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurogranin (NRGN) is the main postsynaptic protein regulating the availability of calmodulin-Ca(2+) in neurons. NRGN is expressed exclusively in the brain, particularly in dendritic spines and has been implicated in spatial learning and hippocampal plasticity. Genetic variation in rs12807809 in the NRGN gene has recently been confirmed to be associated with schizophrenia in a meta-analysis of genome-wide association studies: the T-allele was found to be genome-wide significantly associated with schizophrenia. Cognitive tests and personality questionnaires were administered in a large sample of healthy subjects. Brain activation was measured with functional magnetic resonance imaging (fMRI) during an episodic memory encoding and retrieval task in a subsample. All subjects were genotyped for NRGN rs12807809. There was no effect of genotype on personality or cognitive measures in the large sample. Homozygote carriers of the T-allele showed better performance in the retrieval task during fMRI. After controlling for memory performance, differential brain activation was evident in the anterior cingulate cortex for the encoding and posterior cingulate regions during retrieval. We could demonstrate that rs12807809 of NRGN is associated with differential neural functioning in the anterior and posterior cingulate. These areas are involved in episodic memory processes and have been implicated in the pathophysiology of schizophrenia in structural and functional imaging as well as postmortem studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.