ArticleCerebral cortex (New York, N.Y. : 1991)2012
Abnormal cortical thickness alterations in fetal alcohol spectrum disorders and their relationships with facial dysmorphology.
Article in Cerebral cortex (New York, N.Y. : 1991), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- White matter microstructure in fetal alcohol spectrum disorders: A systematic review of diffusion tensor imaging studies.Human brain mapping · 2019Pooled it
- Impact of Prenatal Alcohol Exposure on the Cerebral Circulation: Potential Implications for Stroke.Advances in experimental medicine and biology · 2026Review
- Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026Review
- Altered neuronal network connectivity in children with fetal alcohol spectrum disorder and its association with inhibitory function.Alcohol, clinical & experimental research · 2025Article
- The association between neighborhood environment, prenatal exposure to alcohol and tobacco, and structural brain development.Frontiers in human neuroscience · 2025Article
- Fetal Alcohol Spectrum Disorders.Current topics in behavioral neurosciences · 2025Review
- Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children.Alcohol, clinical & experimental research · 2024Article
- Delayed cortical thinning in children and adolescents with prenatal alcohol exposure.Alcohol, clinical & experimental research · 2023Article
- Ethanol exposure disrupted the formation of radial glial processes and impaired the generation and migration of outer radial glial cells in forebrain organoids derived from human embryonic stem cells.Experimental neurology · 2023Article
- Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023Review
- Spectral-based thickness profiling of the corpus callosum enhances anomaly detection in fetal alcohol spectrum disorders.Frontiers in neuroscience · 2023Article
- Brain structural differences in children with fetal alcohol spectrum disorder and its subtypes.Frontiers in neuroscience · 2023Article
- Gene-alcohol interactions in birth defects.Current topics in developmental biology · 2023Article
- Trajectories of brain white matter development in young children with prenatal alcohol exposure.Human brain mapping · 2022Article
- The impact of prenatal alcohol exposure on gray matter volume and cortical surface area of 2 to 3-year-old children in a South African birth cohort.Alcoholism, clinical and experimental research · 2022Article
- Distinctive neural correlates of phonological and reading impairment in fetal alcohol-exposed adolescents with and without facial dysmorphology.Neuropsychologia · 2022Article
- Corticostriatal Circuit Models of Cognitive Impairments Induced by Fetal Exposure to Alcohol.Biological psychiatry · 2021Review
- Disruptions in global network segregation and integration in adolescents and young adults with fetal alcohol spectrum disorder.Alcoholism, clinical and experimental research · 2021Article
- Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats.Neurobiology of learning and memory · 2019Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Accumulating evidence from structural brain imaging studies on individuals with fetal alcohol spectrum disorder (FASD) has supported links between prenatal alcohol exposure and brain morphological deficits. Although global and regional volumetric reductions appear relatively robust, the effects of alcohol exposure on cortical thickness and relationships with facial dysmorphology are not yet known. The structural magnetic resonance imaging data from 69 children and adolescents with FASD and 58 nonexposed controls collected from 3 sites were examined using FreeSurfer to detect cortical thickness changes across the entire brain in FASD and their associations with facial dysmorphology. Controlling for brain size, subjects with FASD showed significantly thicker cortices than controls in several frontal, temporal, and parietal regions. Analyses conducted within site further revealed prominent group differences in left inferior frontal cortex within all 3 sites. In addition, increased inferior frontal thickness was significantly correlated with reduced palpebral fissure length. Consistent with previous reports, findings of this study are supportive of regional increases in cortical thickness serving as a biomarker for disrupted brain development in FASD. Furthermore, the significant associations between thickness and dysmorphic measures suggest that the severity of brain anomalies may be reflected by that of the face.
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