Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2011
Effects of high- and low-velocity resistance training on the contractile properties of skeletal muscle fibers from young and older humans.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07205133 (Effectiveness of Whole Body Vibration Therapy and Usual Care Compared to Usual Care in Improving Muscle Mass, Strength and Function in Older Adults), which is not on this map. Cited by 55 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Whole Body Vibration Therapy and Usual Care Compared to Usual Care in Improving Muscle Mass, Strength and Function in Older Adults
Who cites it
55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Does High-Velocity Resistance Exercise Elicit Greater Physical Function Benefits Than Traditional Resistance Exercise in Older Adults? A Systematic Review and Network Meta-Analysis of 79 Trials.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Pooled it
- Comparison of Power Training vs Traditional Strength Training on Physical Function in Older Adults: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Improvements in skeletal muscle fiber size with resistance training are age-dependent in older adults: a systematic review and meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Pooled it
- Resistance training induced changes in strength and specific force at the fiber and whole muscle level: a meta-analysis.European journal of applied physiology · 2019Pooled it
- Effect of repetition duration during resistance training on muscle hypertrophy: a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Relationship of Physical Function to Single Muscle Fiber Contractility in Older Adults: Effects of Resistance Training With and Without Caloric Restriction.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Trial
- High-speed resistance training vs. low-speed resistance training on body composition and physical function in adults with sarcopenic obesity.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Maximal eccentric-concentric strength determines stretch-shortening cycle leg power across biological sexes.Scientific reports · 2026Article
- The effects and post-exercise energy metabolism characteristics of different high-intensity interval training in obese adults.Scientific reports · 2025Article
- The Structural Adaptations That Mediate Mechanical Load-Induced Changes in Muscle Mass.Advances in experimental medicine and biology · 2025Review
- Reliability and Validity of the Rate of Force Development for Quadriceps in Older Patients with Cardiovascular Disease.Journal of clinical medicine · 2024Article
- Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice.Aging cell · 2024Article
- Effects of Resistance Training Techniques on Metabolic Responses in Trained Males.International journal of exercise science · 2024Article
- Article
- Revisiting specific force loss in human permeabilized single skeletal muscle fibers obtained from older individuals.American journal of physiology. Cell physiology · 2023Article
- Myofiber hypertrophy adaptations following 6 weeks of low-load resistance training with blood flow restriction in untrained males and females.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Body composition, cardiorespiratory fitness, and neuromuscular adaptations induced by a home-based whole-body high intensity interval training.Journal of exercise science and fitness · 2023Article
- Understanding altered contractile properties in advanced age: insights from a systematic muscle modelling approach.Biomechanics and modeling in mechanobiology · 2023Article
- Reduced cardiac muscle power with low ATP simulating heart failure.Biophysical journal · 2022Article
- Long-term administration of red ginseng non-saponin fraction rescues the loss of skeletal muscle mass and strength associated with aging in mice.Journal of ginseng research · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
A two-arm, prospective, randomized, controlled trial study was conducted to investigate the effects of movement velocity during progressive resistance training (PRT) on the size and contractile properties of individual fibers from human vastus lateralis muscles. The effects of age and sex were examined by a design that included 63 subjects organized into four groups: young (20-30 yr) men and women, and older (65-80 yr) men and women. In each group, one-half of the subjects underwent a traditional PRT protocol that involved shortening contractions at low velocities against high loads, while the other half performed a modified PRT protocol that involved contractions at 3.5 times higher velocity against reduced loads. Muscles were sampled by needle biopsy before and after the 14-wk PRT program, and functional tests were performed on permeabilized individual fiber segments isolated from the biopsies. We tested the hypothesis that, compared with low-velocity PRT, high-velocity PRT results in a greater increase in the cross-sectional area, force, and power of type 2 fibers. Both types of PRT increased the cross-sectional area, force, and power of type 2 fibers by 8-12%, independent of the sex or age of the subject. Contrary to our hypothesis, the velocity at which the PRT was performed did not affect the fiber-level outcomes substantially. We conclude that, compared with low-velocity PRT, resistance training performed at velocities up to 3.5 times higher against reduced loads is equally effective for eliciting an adaptive response in type 2 fibers from human skeletal muscle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.