ArticleAmerican journal of respiratory and critical care medicine2011
Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study.
Article in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Incidence of primary graft dysfunction and its associated risk factors after lung transplantation: a systematic review and meta-analysis.Surgery today · 2025Pooled it
- Pooled it
- Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.American journal of respiratory and critical care medicine · 2014Trial
- CT-adipose measures identify severe SARS-CoV-2 risk beyond traditional obesity metrics: a C4R cohort study.BMC pulmonary medicine · 2026Article
- Machine learning analysis identifies key predictors of baseline lung allograft dysfunction and increased mortality in lung transplant patients.JHLT open · 2026Article
- Frailty assessment and candidate optimization before cardiothoracic transplantation.JHLT open · 2026Article
- Semaglutide as a potential tool in pre-lung transplant weight loss optimization.JCEM case reports · 2026Article
- Early post-lung transplant weight gain is associated with increased long-term recipient survival.JTCVS open · 2026Article
- Lung Ischemia-Reperfusion Injury in Lung Transplant Surgery: Where Do We Stand?Antioxidants (Basel, Switzerland) · 2025Review
- Synergistic Integration of Multimodal Metabolic and Bariatric Interventions Transforming Transplant Care.Journal of clinical medicine · 2025Review
- Tolerability and Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists in Lung Transplant Recipients: A Single Center Report.Transplantation proceedings · 2025Article
- Analysis of Primary Graft Dysfunction (PGD) Risk Factors in Lung Transplantation (LuTx) Patients.Clinics and practice · 2024Article
- Early serum biomarkers to characterise different phenotypes of primary graft dysfunction after lung transplantation: a systematic scoping review.ERJ open research · 2024Article
- Baseline Lung Allograft Dysfunction After Bilateral Lung Transplantation Is Associated With an Increased Risk of Death: Results From a Multicenter Cohort Study.Transplantation direct · 2024Article
- Lung Donation and Transplant Recipient Outcomes at Independent vs Hospital-Based Donor Care Units.JAMA network open · 2024Article
- Impact of recipient and donor pretransplantation body mass index on early postosperative complications after lung transplantation.BMC pulmonary medicine · 2024Observational
- Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Mitigating the risk of inflammatory type primary graft dysfunction by applying an integrated approach to assess, modify and match risk factors in lung transplantation.Frontiers in transplantation · 2024Article
- Body Mass Index and Cause-Specific Mortality after Lung Transplantation in the United States.Annals of the American Thoracic Society · 2023Article
- Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers.World journal of transplantation · 2023Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
18 authors at 12 institutions in 1 country.
Funding
Abstract
rationaleObesity has been linked to acute lung injury and is a risk factor for early mortality after lung transplantation.
objectivesTo examine the associations of obesity and plasma adipokines with the risk of primary graft dysfunction after lung transplantation.
methodsWe performed a prospective cohort study of 512 adult lung transplant recipients with chronic obstructive pulmonary disease or interstitial lung disease enrolled in the Lung Transplant Outcomes Group Study. In a nested case-control study, we measured plasma leptin, adiponectin, and resistin before lung transplantation and 6 and 24 hours after lung transplantation in 40 cases of primary graft dysfunction and 80 control subjects. Generalized linear mixed models and logistic regression were used to estimate risk ratios and odds ratios. MEASUREMENTS AND MAIN
resultsGrade 3 primary graft dysfunction developed within 72 hours of transplantation in 29% participants. Obesity was associated with a twofold increased risk of primary graft dysfunction (adjusted risk ratio 2.1; 95% confidence interval, 1.7-2.6). The risk of primary graft dysfunction increased by 40% (confidence interval, 30–50%) for each 5 kg/m(2) increase in body mass index after accounting for center, diagnosis, cardiopulmonary bypass, and transplant procedure. Higher plasma leptin levels were associated with a greater risk of primary graft dysfunction (sex-adjusted P = 0.02). The associations of both obesity and leptin with primary graft dysfunction tended to be stronger among those who did not undergo cardiopulmonary bypass.
conclusionsObesity is an independent risk factor for primary graft dysfunction after lung transplantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.