ReviewAmerican journal of respiratory and critical care medicine2011
The state of genome-wide association studies in pulmonary disease: a new perspective.
Review in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interleukin-13 -1112 C/T promoter polymorphism confers risk for COPD: a meta-analysis.PloS one · 2013Pooled it
- Matrix metalloproteinase-9 -1562C/T promoter polymorphism confers risk for COPD: a meta-analysis.PloS one · 2013Pooled it
- Carotid body removal normalizes arterial blood pressure and respiratory frequency in offspring of protein-restricted mothers.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs.BMC pulmonary medicine · 2018Article
- Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Bronchoabsorption; a novel bronchoscopic technique to improve biomarker sampling of the airway.Respiratory research · 2015Article
- Article
- Article
- Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury.Pulmonary circulation · 2013Article
- The impact of personalised therapies on respiratory medicine.European respiratory review : an official journal of the European Respiratory Society · 2013Article
- Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.PLoS genetics · 2013Article
- The next generation of complex lung genetic studies.American journal of respiratory and critical care medicine · 2012Review
- The epigenetic lorax: gene-environment interactions in human health.Epigenomics · 2012Review
- A pilot study of host genetic variants associated with influenza-associated deaths among children and young adults.Emerging infectious diseases · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
With rapid advances in our knowledge of the human genome and increasing availability of high-throughput investigative technology, genome-wide association (GWA) studies have recently gained marked popularity. As an unbiased approach to identifying genomic regions of importance in complex human disease, the results of such studies have the potential to illuminate novel causal pathways, guide mechanistic research, and aid in prediction of disease risk. The use of a genome-wide approach presents considerable methodological and statistical challenges, and properly conducted studies are essential to avoid false-positive results. A total of 22 GWA studies have been published in pulmonary medicine thus far, implicating several intriguing genomic regions in the determination of pulmonary function measures, onset of asthma, and susceptibility to chronic obstructive pulmonary disease. Many questions remain, however, as most identified genetic variants contribute only nominally to overall disease risk, genetic disease mechanisms remain uncertain, and disease-associated variants are not consistent across studies. Perhaps most fundamentally, the association signals identified have not yet been traced to causal variants. This perspective will review the current state of GWA studies in pulmonary disease. We begin with an introduction to the hypothesis, principles, and limitations of this type of genome-wide approach, highlight key points from available studies, and conclude by addressing future approaches to better understand the genetics of complex pulmonary disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.