ArticleBioinformatics (Oxford, England)2011
A powerful approach for association analysis incorporating imprinting effects.
Article in Bioinformatics (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- A powerful parent-of-origin effects test for qualitative traits on X chromosome in general pedigrees.BMC bioinformatics · 2018Article
- Generalized disequilibrium test for association in qualitative traits incorporating imprinting effects based on extended pedigrees.BMC genetics · 2017Article
- Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- A powerful association test for qualitative traits incorporating imprinting effects using general pedigree data.Journal of human genetics · 2015Article
- A model for family-based case-control studies of genetic imprinting and epistasis.Briefings in bioinformatics · 2014Article
- Detection of parent-of-origin effects for quantitative traits using general pedigree data.Journal of genetics · 2014Article
- Robust joint analysis with data fusion in two-stage quantitative trait genome-wide association studies.Computational and mathematical methods in medicine · 2013Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
motivationFor a diallelic marker locus, the transmission disequilibrium test (TDT) is a simple and powerful design for genetic studies. The TDT was originally proposed for use in families with both parents available (complete nuclear families) and has further been extended to 1-TDT for use in families with only one of the parents available (incomplete nuclear families). Currently, the increasing interest of the influence of parental imprinting on heritability indicates the importance of incorporating imprinting effects into the mapping of association variants.
resultsIn this article, we extend the TDT-type statistics to incorporate imprinting effects and develop a series of new test statistics in a general two-stage framework for association studies. Our test statistics enjoy the nature of family-based designs that need no assumption of Hardy-Weinberg equilibrium. Also, the proposed methods accommodate complete and incomplete nuclear families with one or more affected children. In the simulation study, we verify the validity of the proposed test statistics under various scenarios, and compare the powers of the proposed statistics with some existing test statistics. It is shown that our methods greatly improve the power for detecting association in the presence of imprinting effects. We further demonstrate the advantage of our methods by the application of the proposed test statistics to a rheumatoid arthritis dataset. CONTACT: wingfung@hku.hk SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.