ArticleJournal of critical care2012
Sepsis: Something old, something new, and a systems view.
Article in Journal of critical care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Trial
- Risk factors for vascular occlusive events and death due to bleeding in trauma patients; an analysis of the CRASH-2 cohort.PloS one · 2012Trial
- Sequential clearance of neutrophil extracellular traps for precision therapy of sepsis.Science advances · 2026Article
- Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study.Metabolites · 2023Article
- Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Identification of key genes associated with sepsis patients infected by staphylococcus aureus through weighted gene co-expression network analysis.American journal of translational research · 2021Article
- Glycoproteoform Profiles of Individual Patients' Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode.Frontiers in immunology · 2020Article
- Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection.Pharmacological research · 2019Review
- Mathematical modeling of septic shock based on clinical data.Theoretical biology & medical modelling · 2019Article
- Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle.Endocrinology · 2018Article
- Upregulation of Heme Oxygenase-1 by Hemin Alleviates Sepsis-Induced Muscle Wasting in Mice.Oxidative medicine and cellular longevity · 2018Article
- On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology.Computers & chemical engineering · 2017Article
- Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption.Scientific reports · 2017Article
- Systolic blood pressure variability in patients with early severe sepsis or septic shock: a prospective cohort study.BMC anesthesiology · 2017Article
- Heart rate time series characteristics for early detection of infections in critically ill patients.Journal of clinical monitoring and computing · 2017Observational
- Systems Medicine-Complexity Within, Simplicity Without.Journal of healthcare informatics research · 2017Article
- From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients.Annals of translational medicine · 2016Article
- The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury.Shock (Augusta, Ga.) · 2016Review
- Sepsis in Buraidah Central Hospital, Qassim, Kingdom of Saudi Arabia.International journal of health sciences · 2016Article
- In Search of a Cure for Sepsis: Taming the Monster in Critical Care Medicine.Journal of innate immunity · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ-organ interaction networks. A central thread that connects these responses is inflammation that, while attempting to defend the body and prevent further harm, causes further damage through the feed-forward, proinflammatory effects of damage-associated molecular pattern molecules. In this review, we address the epidemiology and current definitions of sepsis and focus specifically on the biologic cascades that comprise the inflammatory response to sepsis. We suggest that attempts to improve clinical outcomes by targeting specific components of this network have been unsuccessful due to the lack of an integrative, predictive, and individualized systems-based approach to define the time-varying, multidimensional state of the patient. We highlight the translational impact of computational modeling and other complex systems approaches as applied to sepsis, including in silico clinical trials, patient-specific models, and complexity-based assessments of physiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.