ArticleJournal of the American Academy of Dermatology2012
Langerhans cells and melanocytes share similar morphologic features under in vivo reflectance confocal microscopy: a challenge for melanoma diagnosis.
Article in Journal of the American Academy of Dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- In vivo imaging characterization of basal cell carcinoma and cutaneous response to high-dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasonography.Journal of the American Academy of Dermatology · 2021Trial
- In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions.Scientific reports · 2021Trial
- Reflectance confocal microscopy in the management of lentigo maligna and lentigo maligna melanoma: a systematic review.JPRAS open · 2026Review
- Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration.International journal of extreme manufacturing · 2025Review
- Limits of Reflectance Confocal Microscopy in Melanoma Diagnosis.Dermatology practical & conceptual · 2024Article
- Confocal findings of an intradermal nevus in a unique anatomical location: A diagnostic pitfall and histopathologic correlation.JAAD case reports · 2023Article
- Retinal microvascular and microstructural alterations in the diagnosis of dermatomyositis: a new approach.Frontiers in medicine · 2023Article
- Langerhans Cells-Revising Their Role in Skin Pathologies.Journal of personalized medicine · 2022Review
- Dermoscopy and Reflectance Confocal Microscopy to Estimate Breslow Index and Mitotic Rate in Primary Melanoma.Dermatology practical & conceptual · 2022Article
- Dendritic cells in reflectance confocal microscopy are a clue for early melanoma diagnosis in extrafacial flat pigmented melanocytic lesions.Experimental dermatology · 2022Article
- Real-Time Reflectance Confocal Microscopy of Cutaneous Graft-versus-Host Disease Correlates with Histopathology.Transplantation and cellular therapy · 2022Article
- Reflectance confocal findings in a large-cell acanthoma with histologic correlation.JAAD case reports · 2021Article
- Langerhans Cells as Morphologic Mimickers of Atypical Melanocytes on Reflectance Confocal Microscopy: A Case Report and Review of the Literature.Dermatology practical & conceptual · 2021Review
- Reflectance confocal microscopy characteristics of oral lichen planus: An analysis of 47 cases in a Chinese cohort.Experimental and therapeutic medicine · 2020Article
- Reduction in Human Epidermal Langerhans Cells with Age Is Associated with Decline in CXCL14-Mediated Recruitment of CD14The Journal of investigative dermatology · 2020Article
- Current and future applications of confocal laser scanning microscopy imaging in skin oncology.Oncology letters · 2019Review
- Introduction to reflectance confocal microscopy and its use in clinical practice.JAAD case reports · 2018Article
- Reflectance confocal microscopy features of labial melanotic macule: Report of three cases.JAAD case reports · 2018Article
- Advances in the use of reflectance confocal microscopy in melanoma.Melanoma management · 2018Review
- Actinic Keratosis and Non-Invasive Diagnostic Techniques: An Update.Biomedicines · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIntraepidermal Langerhans cells (ILC) are difficult to differentiate from melanocytes under reflectance confocal microscopy (RCM) and their presence may simulate pagetoid spread of melanocytes on RCM images.
objectiveWe sought to correlate bright round and dendritic cells in a pagetoid pattern identified on RCM with findings of conventional histopathology and immunohistochemistry for lesions that were falsely diagnosed as melanoma by RCM.
methodsThis retrospective study included histopathologically proven nevi, imaged by RCM, which displayed bright cells in a pagetoid pattern (BCPP) under RCM, resulting in the incorrect RCM diagnosis of melanoma. Morphological comparisons were made between RCM images of nevi showing BCPP, histopathologically proven melanomas displaying BCPP, and biopsy-proven nevi without BCPP.
resultsWe identified 24 nevi that were falsely diagnosed as melanoma by RCM because of the presence of BCPP. These pagetoid cells on RCM corresponded on histopathology to ILC with a high density in 23 of the 24 nevi (95%) and to melanocytes in 7 of the 24 nevi (29%). Among 6 melanomas displaying BCPP on RCM, ILC with high density were observed histopathologically in 5 of the 6 cases (83%) and pagetoid melanocytes were seen in all 6 cases (100%). LIMITATIONS: The results cannot be generalized to clinically banal-appearing nevi.
conclusionsAlthough the finding of BCPP is a useful RCM feature for the diagnosis of melanoma, it does not always imply the presence of pagetoid melanocytes but may at times represent ILC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.