Evidence map›Paper›PMID 21798354›Full record

ArticleNeuroImage2011

Functional principal component model for high-dimensional brain imaging.

Vadim Zipunnikov, Brian Caffo, David M Yousem, Christos Davatzikos, Brian S Schwartz, Ciprian Crainiceanu

Abstract read
In one paragraph

Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Multi-task Learning with High-Dimensional Noisy Images.Journal of the American Statistical Association · 2024
    Article
  10. Article
  11. Article
  12. Identifying regions of interest in mammogram images.Statistical methods in medical research · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Bayesian Scalar on Image Regression With Nonignorable Nonresponse.Journal of the American Statistical Association · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vadim ZipunnikovDepartment of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA. vzipunni@jhsph.edu
Brian Caffo
David M Yousem
Christos Davatzikos
Brian S Schwartz
Ciprian Crainiceanu

Funding

Statistical Methods for Multilevel Multivariate Functional StudiesR01NS060910 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Ciprian M Crainiceanu · 2009 to 2026
$8.3M
Statistical methods for large n and p problemsR01EB012547 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI CAFFO, BRIAN SCOTT · 2010 to 2016
$2.1M
NIBIB NIH HHS EB012547NIBIB NIH HHS R01 EB012547NINDS NIH HHS R01 NS060910NINDS NIH HHS R01NS060910
6 · The paper itself

Abstract

We explore a connection between the singular value decomposition (SVD) and functional principal component analysis (FPCA) models in high-dimensional brain imaging applications. We formally link right singular vectors to principal scores of FPCA. This, combined with the fact that left singular vectors estimate principal components, allows us to deploy the numerical efficiency of SVD to fully estimate the components of FPCA, even for extremely high-dimensional functional objects, such as brain images. As an example, a FPCA model is fit to high-resolution morphometric (RAVENS) images. The main directions of morphometric variation in brain volumes are identified and discussed.

Indexed as

Models, NeurologicalBrain MappingHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingPrincipal Component Analysis

Identifiers

PMID21798354
PMCPMC3169674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.