ArticleJournal of ethnopharmacology2011
Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers.
Article in Journal of ethnopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Ursolic acid: context-dependent redox activity on oxidative stress and its toxicological implications.Archives of toxicology · 2026Review
- Antiparasitic triterpenic ester and ursolic acid lipid nanocapsule design, cytotoxicity, and permeability evaluation for oral delivery.Frontiers in drug delivery · 2026Article
- Combined Effects of Diosmin, Hesperidin,International journal of molecular sciences · 2025Article
- Biopharmaceutical profiling of anti-infective sanggenons fromInternational journal of pharmaceutics: X · 2024Article
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges.Drug design, development and therapy · 2024Review
- Crosstalk between Myopia and Inflammation: A Mini Review.International journal of medical sciences · 2024Review
- Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents.International journal of molecular sciences · 2023Article
- Exploiting the Integrated Valorization ofInternational journal of molecular sciences · 2023Article
- Oral Pharmacokinetics of Hydroxycinnamic Acids: An Updated Review.Pharmaceutics · 2022Review
- Fallopia Japonica and Prunella vulgaris inhibit myopia progression by suppressing AKT and NFκB mediated inflammatory reactions.BMC complementary medicine and therapies · 2022Article
- Evaluation of the Intestinal Permeability of Rosmarinic Acid fromMolecules (Basel, Switzerland) · 2022Article
- Formulation, Characterization and Permeability Studies of Fenugreek (Molecules (Basel, Switzerland) · 2022Article
- Silver and gold nanoparticles induced differential antimicrobial potential in calli cultures of Prunella vulgaris.BMC chemistry · 2022Article
- Investigation of the Uptake and Transport of Aspirin Eugenol Ester in the Caco-2 Cell Model.Frontiers in pharmacology · 2022Article
- Water-ExtractedFrontiers in pharmacology · 2022Article
- Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases.International journal of molecular sciences · 2021Review
- Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential.International journal of molecular sciences · 2021Review
- Nanoformulations of Ursolic Acid: A Modern Natural Anticancer Molecule.Frontiers in pharmacology · 2021Review
- Article
- Full-Spectrum Analysis of Bioactive Compounds in Rosemary (Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
ethnopharmacological relevanceRosmarinic acid (RA), a caffeic acid-related compound found in high concentrations in Prunella vulgaris (self-heal), and ursolic acid (UA), a pentacyclic triterpene acid concentrated in Salvia officinalis (sage), have been traditionally used to treat inflammation in the mouth, and may also be beneficial for gastrointestinal health in general. AIM OF THE STUDY: To investigate the permeabilities of RA and UA as pure compounds and in Prunella vulgaris and Salvia officinalis ethanol extracts across human intestinal epithelial Caco-2 cell monolayers. MATERIALS AND
methodsThe permeabilities and phase II biotransformation of RA and UA as pure compounds and in herbal extracts were compared using Caco-2 cells with HPLC detection.
resultsThe apparent permeability coefficient (P(app)) for RA and RA in Prunella vulgaris extracts was 0.2 ± 0.05 × 10(-6)cm/s, significantly increased to 0.9 ± 0.2 × 10(-6)cm/s after β-glucuronidase/sulfatase treatment. P(app) for UA and UA in Salvia officinalis extract was 2.7 ± 0.3 × 10(-6)cm/s and 2.3 ± 0.5 × 10(-6)cm/s before and after β-glucuronidase/sulfatase treatment, respectively. Neither compound was affected in permeability by the herbal extract matrix.
conclusionRA and UA in herbal extracts had similar uptake as that found using the pure compounds, which may simplify the prediction of compound efficacy, but the apparent lack of intestinal glucuronidation/sulfation of UA is likely to further enhance the bioavailability of that compound compared with RA.
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Registered trials
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