ArticleDevelopmental biology2011
Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 77 citations in OpenAlex.
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- Nkx2.7 is a conserved regulator of craniofacial development.Nature communications · 2025Article
- The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis.JCI insight · 2024Article
- Development of a cell line from skeletal trunk muscle of the fishCytotechnology · 2023Article
- Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology.Marine biotechnology (New York, N.Y.) · 2023Review
- Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions.Advances in anatomy, embryology, and cell biology · 2023Article
- Isolation, Culture, and Analysis of Zebrafish Myofibers and Associated Muscle Stem Cells to Explore Adult Skeletal Myogenesis.Methods in molecular biology (Clifton, N.J.) · 2023Article
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- Evolution of Somite Compartmentalization: A View FromFrontiers in cell and developmental biology · 2021Article
- Notch Signaling Regulates Muscle Stem Cell Homeostasis and Regeneration in a Teleost Fish.Frontiers in cell and developmental biology · 2021Article
- Circadian regulation of muscle growth independent of locomotor activity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Development and patterning of rib primordia are dependent on associated musculature.Developmental biology · 2020Article
- Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis.eLife · 2020Article
- Fgf-driven Tbx protein activities directly induceDevelopment (Cambridge, England) · 2020Article
- Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Myogenin promotes myocyte fusion to balance fibre number and size.Nature communications · 2018Article
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- In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw.PLoS genetics · 2017Article
- Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.Developmental biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Myogenic regulatory factors of the myod family (MRFs) are transcription factors essential for mammalian skeletal myogenesis. Here we show that a mutation in the zebrafish myod gene delays and reduces early somitic and pectoral fin myogenesis, reduces miR-206 expression, and leads to a persistent reduction in somite size until at least the independent feeding stage. A mutation in myog, encoding a second MRF, has little obvious phenotype at early stages, but exacerbates the loss of somitic muscle caused by lack of Myod. Mutation of both myod and myf5 ablates all skeletal muscle. Haploinsufficiency of myod leads to reduced embryonic somite muscle bulk. Lack of Myod causes a severe reduction in cranial musculature, ablating most muscles including the protractor pectoralis, a putative cucullaris homologue. This phenotype is accompanied by a severe dysmorphology of the cartilaginous skeleton and failure of maturation of several cranial bones, including the opercle. As myod expression is restricted to myogenic cells, the data show that myogenesis is essential for proper skeletogenesis in the head.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.