ArticleDevelopmental biology2011
The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Rapid actin filament turnover maintains cortical connectivity while allowing for cell cortex deformation and flow.bioRxiv : the preprint server for biology · 2026Article
- Arp2/3 involvement in intercellular bridge membrane fluctuations and constriction during neural stem cell divisions.iScience · 2026Article
- The Rac1 homolog CED-10 is a component of the MES-1/SRC-1 pathway for asymmetric division of the Caenorhabditis elegans EMS blastomere.Genetics · 2025Article
- Branched-chain actin dynamics polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains.Science advances · 2023Article
- Push or pull: how cytoskeletal crosstalk facilitates nuclear movement through 3D environments.Physical biology · 2022Review
- Two mechanisms drive pronuclear migration in mouse zygotes.Nature communications · 2021Article
- Gamete Nuclear Migration in Animals and Plants.Frontiers in plant science · 2019Review
- The ARP2/3 complex prevents excessive formin activity during cytokinesis.Molecular biology of the cell · 2019Article
- A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis ineLife · 2018Article
- Cytoskeletal control of nuclear migration in neurons and non-neuronal cells.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- WASP-Arp2/3-dependent actin polymerization influences fusogen localization during cell-cell fusion inBiology open · 2017Article
- A GAP that Divides.F1000Research · 2017Review
- Cell Biology of the Caenorhabditis elegans Nucleus.Genetics · 2017Review
- LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.The Journal of cell biology · 2016Article
- Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells.Development (Cambridge, England) · 2016Article
- Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia.Developmental biology · 2013Article
- Article
- The PAR network: redundancy and robustness in a symmetry-breaking system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.Cytoskeleton (Hoboken, N.J.) · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Regulated movements of the nucleus are essential during zygote formation, cell migrations, and differentiation of neurons. The nucleus moves along microtubules (MTs) and is repositioned on F-actin at the cellular cortex. Two families of nuclear envelope proteins, SUN and KASH, link the nucleus to the actin and MT cytoskeletons during nuclear movements. However, the role of actin nucleators in nuclear migration and positioning is poorly understood. We show that the branched actin nucleator, Arp2/3, affects nuclear movements throughout embryonic and larval development in C. elegans, including nuclear migrations in epidermal cells and neuronal precursors. In one-cell embryos the migration of the male pronucleus to meet the female pronucleus after fertilization requires Arp2/3. Loss of Arp2/3 or its activators changes the dynamics of non-muscle myosin, NMY-2, and alters the cortical accumulation of posterior PAR proteins. Reduced establishment of the posterior microtubule cytoskeleton in Arp2/3 mutants correlates with reduced male pronuclear migration. The UNC-84/SUN nuclear envelope protein that links the nucleus to the MT and actin cytoskeleton is known to regulate later nuclear migrations. We show here it also positions the male pronucleus. These studies demonstrate a global role for Arp2/3 in nuclear migrations. In the C. elegans one-cell embryo Arp2/3 promotes the establishment of anterior/posterior polarity and promotes MT growth that propels the anterior migration of the male pronucleus. In contrast with previous studies emphasizing pulling forces on the male pronucleus, we propose that robust MT nucleation pushes the male pronucleus anteriorly to join the female pronucleus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.