ArticleBMC evolutionary biology2011
Conversion events in gene clusters.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Emergence of a Chimeric Globin Pseudogene and Increased Hemoglobin Oxygen Affinity Underlie the Evolution of Aquatic Specializations in Sirenia.Molecular biology and evolution · 2019Article
- Gene tree species tree reconciliation with gene conversion.Journal of mathematical biology · 2019Article
- Article
- Review
- Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.Molecular biology and evolution · 2015Article
- Article
- Origins of P450 diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Evolution of hemoglobin and its genes.Cold Spring Harbor perspectives in medicine · 2012Article
- Genomic structure and evolution of multigene families: "flowers" on the human genome.International journal of evolutionary biology · 2012Article
- Revealing mammalian evolutionary relationships by comparative analysis of gene clusters.Genome biology and evolution · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundGene clusters containing multiple similar genomic regions in close proximity are of great interest for biomedical studies because of their associations with inherited diseases. However, such regions are difficult to analyze due to their structural complexity and their complicated evolutionary histories, reflecting a variety of large-scale mutational events. In particular, conversion events can mislead inferences about the relationships among these regions, as traced by traditional methods such as construction of phylogenetic trees or multi-species alignments.
resultsTo correct the distorted information generated by such methods, we have developed an automated pipeline called CHAP (Cluster History Analysis Package) for detecting conversion events. We used this pipeline to analyze the conversion events that affected two well-studied gene clusters (α-globin and β-globin) and three gene clusters for which comparative sequence data were generated from seven primate species: CCL (chemokine ligand), IFN (interferon), and CYP2abf (part of cytochrome P450 family 2). CHAP is freely available at http://www.bx.psu.edu/miller_lab.
conclusionsThese studies reveal the value of characterizing conversion events in the context of studying gene clusters in complex genomes.
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Registered trials
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