ArticleDiagnostic pathology2011
Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis.
Article in Diagnostic pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- A clinicopathological study of eight cases presenting a Biphasic structure: A distinct variant of pulmonary carcinoma.Histology and histopathology · 2026Article
- Epithelial-myoepithelial carcinoma of the lung: a case report and literature review.Journal of cancer research and clinical oncology · 2026Review
- Primary endobronchial epithelial-myoepithelial carcinoma: A case report and literature review.Experimental and therapeutic medicine · 2025Article
- Primary Pulmonary Epithelial-Myoepithelial Carcinoma With Prominent Reactive Pneumocytes: Clinicopathological Insights Into a Rare Case and Literature Review.Pathology international · 2025Review
- Pulmonary Epithelial-Myoepithelial Carcinoma.Journal of oncology · 2022Review
- Primary salivary gland tumors of the lung: Two cases date report and literature review.Respiratory medicine case reports · 2021Article
- [A Rare Case of Pulmonary Epithelial-myoepithelial Carcinoma: Case Report and Literature Review].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Article
- The First Reported Pediatric Case of Primary Myoepithelial Carcinoma Involving the Whole Lung: Surgical Radical Treatment and Prosthesis Implant.European journal of pediatric surgery reports · 2020Article
- Epithelial-myoepithelial carcinoma of the lung: a case report.Surgical case reports · 2018Article
- Adenomyoepithelioma of the breast with late pulmonary metastases - case report and review of the literature.Journal of cardiothoracic surgery · 2016Review
- A rare case of primary peripheral epithelial myoepithelial carcinoma of lung: Case report and literature review.Medicine · 2016Review
- Endobronchial laser ablation in the management of epithelial-myoepithelial carcinoma of the trachea.Respiratory medicine case reports · 2015Article
- Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma.Diagnostic pathology · 2014Article
- Epithelial-myoepithelial carcinoma of the trachea-a rare entity case report.Journal of thoracic disease · 2014Article
- Primary epithelial myoepithelial lung carcinoma.The Korean journal of thoracic and cardiovascular surgery · 2014Article
- [Epithelial-myoepithelial carcinoma of the trachea. Case report and review of the literature].Der Pathologe · 2013Review
- The alveolar epithelial differentiation of glandular inner lining cells in a mucoepidermoid carcinoma of the lung: a case report.Diagnostic pathology · 2012Article
- Primary epithelial myoepithelial carcinoma of lung, reporting of a rare entity, its molecular histogenesis and review of the literature.Case reports in pathology · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tracheobronchial submucous glands can be considered the pulmonary equivalent of minor salivary glands and therefore they can develop most of the tumours originated in these. Nevertheless, in spite of the wide distribution of this kind of glands along the tracheobronchial tree, pulmonary salivary gland-like neoplasms are not very frequent. Among them, the most frequent are mucoepidermoid and adenoid cystic carcinomas. On the contrary, pulmonary neoplasms showing a mixture of epithelial and myoepithelial elements are extraordinary infrequent, with only 11 cases collected from literature.We present the case of a 76 year-old woman with no interesting pathological history, to whom a pulmonary nodule is detected during a study of unknown origin neutropenia. An upper right lobectomy is performed.After macro and microscopic study, the diagnosis of pulmonary epithelial-myoepithelial tumour is made. It is a low malignant potential tumour with capacity to locally recur and less frequently to metastasize. Our case has the peculiarity of not being connected neither to visceral pleura nor to bronchial tree; we have not found this characteristic in any literature reviewed case.These tumours have been named in a lot of different ways, including adenomyoepithelioma, epithelial-myoepithelial tumour, epithelial-myoepithelial carcinoma or epithelial-myoepithelial tumour of uncertain malignant potential.The p27/kip-1 protein plays a fundamental role in the development of these neoplasms. As we have verified in our case, its aberrant cytoplasmic location, besides its proved oncogenic function, would favour the proliferation of stem cells, which would explain both dual phenotype with presence of myoepithelial cells without connection with the bronchial tree, and TTF-1 immunostaining in epithelial cells.
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