ArticleAlcoholism, clinical and experimental research2012
A role for dynamin in triggering ethanol tolerance.
Article in Alcoholism, clinical and experimental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Beyond Stigma-Integrating Neurobiology, Genetics, and Awareness Integration Theory in Addiction Recovery.Psychology research and behavior management · 2026Article
- A Brief Overview of Ethanol Tolerance and Its Potential Association with Circadian Rhythm inInternational journal of molecular sciences · 2024Review
- Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models.International journal of molecular sciences · 2024Review
- Repeated ethanol intoxications of Drosophila melanogaster adults increases the resistance to ethanol of their progeny.Alcoholism, clinical and experimental research · 2021Article
- Alcohol-induced Aggression.Neuroscience insights · 2021Review
- Alcohol Causes Lasting Differential Transcription inGenetics · 2020Article
- SNARE Complex-Associated Proteins and Alcohol.Alcoholism, clinical and experimental research · 2020Review
- F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol-Induced Behaviors in Drosophila.Alcoholism, clinical and experimental research · 2019Article
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies inFrontiers in physiology · 2018Review
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.Genes, brain, and behavior · 2016Article
- A DNA element in the slo gene modulates ethanol tolerance.Alcohol (Fayetteville, N.Y.) · 2016Article
- Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2015Review
- Susceptibility to ethanol withdrawal seizures is produced by BK channel gene expression.Addiction biology · 2014Article
- Alcohol-induced histone acetylation reveals a gene network involved in alcohol tolerance.PLoS genetics · 2013Article
- Drosophila melanogaster as a model to study drug addiction.Human genetics · 2012Review
- Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.Journal of genetic syndromes & gene therapy · 2012Article
- Article
- Homeostatic control of neural activity: a Drosophila model for drug tolerance and dependence.International review of neurobiology · 2011Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA prevailing hypothesis is that the set of genes that underlie the endophenotypes of alcoholism overlap with those responsible for the addicted state. Functional ethanol tolerance, an endophenotype of alcoholism, is defined as a reduced response to ethanol caused by prior ethanol exposure. The neuronal origins of functional rapid tolerance are thought to be a homeostatic response of the nervous system that counters the effects of the drug. Synaptic proteins that regulate neuronal activity are an important evolutionarily conserved target of ethanol.
methodsWe used mutant analysis in Drosophila to identify synaptic proteins that are important for the acquisition of rapid tolerance to sedation with ethanol. Tolerance was assayed by sedating flies with ethanol vapor and comparing the recovery time of flies after their first sedation and their second sedation. Temperature-sensitive paralytic mutants that alter key facets of synaptic neurotransmission, such as the propagation of action potentials, synaptic vesicle fusion, exocytosis, and endocytosis, were tested for the ability to acquire functional tolerance at both the permissive and restrictive temperatures.
resultsThe shibire gene encodes Drosophila Dynamin. We tested 2 temperature-sensitive alleles of the gene. The shi(ts1) allele blocked tolerance at both the permissive and restrictive temperatures, while shi(ts2) blocked only at the restrictive temperature. Using the temperature-sensitive property of shi(ts2) , we showed that Dynamin function is required concomitant with exposure to ethanol. A temperature-sensitive allele of the Syntaxin 1A gene, Syx1A(3-69), also blocked the acquisition of ethanol tolerance.
conclusionsWe have shown that shibire and Syntaxin 1A are required for the acquisition of rapid functional tolerance to ethanol. Furthermore, the shibire gene product, Dynamin, appears to be required for an immediate early response to ethanol that triggers a cellular response leading to rapid functional tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.