ReviewBritish journal of pharmacology2012
Microvascular responsiveness in obesity: implications for therapeutic intervention.
Review in British journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 72 citations in OpenAlex.
- Reverse sural artery flap for lower extremity reconstruction: a multicenter retrospective analysis of success and failure patterns.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Article
- Obesity accelerates cardiovascular ageing.European heart journal · 2025Review
- Improvement of Microvascular Function in Patients with Morbid Obesity After Bariatric Surgery Revealed by Imaging Photoplethysmography.Obesity surgery · 2025Article
- LDL-c/HDL-c Ratio and NADPH-Oxidase-2-Derived Oxidative Stress as Main Determinants of Microvascular Endothelial Function in Morbidly Obese Subjects.Antioxidants (Basel, Switzerland) · 2024Article
- Impaired Capillary Recruitment Capacity in Obesity: A Subgroup Analysis of Prospective Observational Study on Anesthesia Effects.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- The weight of obesity in hypertrophic cardiomyopathy.Clinical medicine (London, England) · 2023Review
- The impact of obesity on the regulation of muscle blood flow during exercise in patients with heart failure with a preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest.Antioxidants (Basel, Switzerland) · 2021Review
- Association Between Obesity and Microvascular Diseases in Patients With Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2021Article
- ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'.Cardiovascular research · 2020Review
- Oxidative Stress in Ischemic Heart Disease.Oxidative medicine and cellular longevity · 2020Review
- Emerging concepts in metabolically healthy obesity.American journal of cardiovascular disease · 2020Review
- Perivascular Adipose Tissue as a Relevant Fat Depot for Cardiovascular Risk in Obesity.Frontiers in physiology · 2018Review
- Article
- Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.SpringerPlus · 2016Article
- Obesity Related Coronary Microvascular Dysfunction: From Basic to Clinical Practice.Cardiology research and practice · 2016Review
- Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes.British journal of pharmacology · 2015Review
- Article
- Overnutrition, mTOR signaling, and cardiovascular diseases.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
unlabelledObesity has detrimental effects on the microcirculation. Functional changes in microvascular responsiveness may increase the risk of developing cardiovascular complications in obese patients. Emerging evidence indicates that selective therapeutic targeting of the microvessels may prevent life-threatening obesity-related vascular complications, such as ischaemic heart disease, heart failure and hypertension. It is also plausible that alterations in adipose tissue microcirculation contribute to the development of obesity. Therefore, targeting adipose tissue arterioles could represent a novel approach to reducing obesity. This review aims to examine recent studies that have been focused on vasomotor dysfunction of resistance arteries in obese humans and animal models of obesity. Particularly, findings in coronary resistance arteries are contrasted to those obtained in other vascular beds. We provide examples of therapeutic attempts, such as use of statins, ACE inhibitors and insulin sensitizers to prevent obesity-related microvascular complications. We further identify some of the important challenges and opportunities going forward. LINKED ARTICLES: This article is part of a themed section on Fat and Vascular Responsiveness. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-3.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.