Evidence map›Paper›PMID 21797831›Full record

ArticleJournal of the American Geriatrics Society2011

Beyond the prescription: medication monitoring and adverse drug events in older adults.

Michael A Steinman, Steven M Handler, Jerry H Gurwitz, Gordon D Schiff, Kenneth E Covinsky

Abstract readCase Reports
In one paragraph

Article in Journal of the American Geriatrics Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.

  1. Pooled it
  2. Identifying high-risk medication: a systematic literature review.European journal of clinical pharmacology · 2014
    Pooled it
  3. Pooled it
  4. Trial
  5. The electronic medication complete communication (EMCContemporary clinical trials · 2016
    Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
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  15. Observational
  16. Article
  17. Review
  18. Article
  19. Perspectives on deprescribing in palliative care.Expert review of clinical pharmacology · 2023
    Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michael A SteinmanDivision of Geriatrics, University of California San Francisco, San Francisco, California, USA. mike.steinman@ucsf.edu
Steven M Handler
Jerry H Gurwitz
Gordon D Schiff
Kenneth E Covinsky
San Francisco VA Medical Center · USUniversity of Massachusetts Chan Medical School · USVA Pittsburgh Healthcare System · US

Funding

Mayo Clinic Center for Translational Science ActivitiesKL2RR024151 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$15.3M
Tools for Optimizing Prescribing, Monitoring and EducationU18HS016973 · AHRQ · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LAMBERT, BRUCE L. · 2007 to 2010
$4.0M
Enhancing the Detection and Management of Adverse Drug Events in the Nursing HomeR01HS018721 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDLER, STEVEN MARK · 2010 to 2013
$2.0M
Midcareer Mentoring Award for Patient-Oriented Research in AgingK24AG029812 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COVINSKY, KENNETH E. · 2007 to 2017
$1.8M
Guideline Adherence in Elders With Multiple ComorbiditiesK23AG030999 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEINMAN, MICHAEL A. · 2008 to 2010
$391k
AHRQ HHS 1R01HS018721-01AHRQ HHS R01 HS018721AHRQ HHS U18 HS016973AHRQ HHS U18HS016973NCRR NIH HHS 5KL2RR024151NCRR NIH HHS KL2 RR024151NIA NIH HHS 1K23AG030999NIA NIH HHS 1K24AG029812-02NIA NIH HHS K23 AG030999NIA NIH HHS K24 AG029812
6 · The paper itself

Abstract

Whether a person will suffer harm from a medication or how severe that harm will be is difficult to predict precisely. As a result, many adverse drug events (ADEs) occur in patients in whom it was reasonable to believe that the drug's benefits exceeded its risks. Improving safety and reducing the burden of ADEs in older adults requires addressing this uncertainty by not only focusing on the appropriateness of the initial prescribing decision, but also by detecting and mitigating adverse events once they have started to occur. Such enhanced monitoring of signs, symptoms, and laboratory parameters can determine whether an adverse event has only mild and short-term consequences or major long-term effects on morbidity and mortality. Although current medication monitoring practices are often suboptimal, several strategies can be leveraged to improve the quality and outcomes of monitoring. These strategies include using health information technology to link pharmacy and laboratory data, prospective delineation of risk, and patient outreach and activation, all within a framework of team-based approaches to patient management. Although many of these strategies are theoretically possible now, they are poorly used and will be difficult to implement without a significant restructuring of medical practice. An enhanced focus on medication monitoring will also require a new conceptual framework to re-engineer the prescribing process. With this approach, prescribing quality does not hinge on static attributes of the initial prescribing decision but entails a dynamic process in which the benefits and harms of drugs are actively monitored, managed, and reassessed over time.

Indexed as

Adverse Drug Reaction Reporting SystemsDrug MonitoringAccidental FallsAgedAngioedemaAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCalcium Channel BlockersGuideline AdherenceHip FracturesHumansHyperkalemiaHypertensionHypotension, OrthostaticInappropriate PrescribingMaleAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCalcium Channel BlockersPrescription Drugs

Identifiers

PMID21797831
PMCPMC3940362
OpenAlexW1792189485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.