Evidence map›Paper›PMID 21797658›Full record

ReviewExpert review of neurotherapeutics2011

Corticosteroid use in neurocysticercosis.

Theodore E Nash, Siddhartha Mahanty, Hector H Garcia, Cysticercosis Group in Peru

Abstract readReview
In one paragraph

Review in Expert review of neurotherapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 66 citations in OpenAlex.

  1. Cysticidal Efficacy of Combined Treatment With Praziquantel and Albendazole for Parenchymal Brain Cysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Human Neurocysticercosis: An Overview.Pathogens (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Review
  14. Current Diagnostic Criteria for Neurocysticercosis.Research and reports in tropical medicine · 2021
    Review
  15. Subarachnoid neurocysticercosis: emerging concepts and treatment.Current opinion in infectious diseases · 2020
    Review
  16. Article
  17. Unique Characteristics of Epilepsy Development in Neurocysticercosis.The American journal of tropical medicine and hygiene · 2020
    Review
  18. Review
  19. Natural History of Treated Subarachnoid Neurocysticercosis.The American journal of tropical medicine and hygiene · 2020
    Article
  20. Controlling the Host Response in Neurocysticercosis.The American journal of tropical medicine and hygiene · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Theodore E NashLaboratory of Parasitic Diseases, NIAID, NIH, 4 Center Drive, Building 4, Room 126, Bethesda, MD 20892, USA.
Siddhartha Mahanty
Hector H Garcia
Cysticercosis Group in Peru
National Institutes of Health · USInstituto Nacional de Enfermedades Neoplásicas · PE

Funding

Studies of neurocysticercosis and animal cestode infectionsZIAAI000846 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NASH, THEODORE · 2009 to 2020
$9.5M
Intramural NIH HHS ZIA AI000846Wellcome Trust 091077
6 · The paper itself

Abstract

The cystic larvae of Taenia solium commonly infect the human nervous system, resulting in neurocysticercosis, a major contributor to seizure disorders in most of the world. Inflammation around the parasites is a hallmark of neurocysticercosis pathophysiology. Although mechanisms regulating this inflammation are poorly understood, anti-inflammatory drugs, particularly corticosteroids, have been long used alone or with anthelmintics to manage disease and limit neurological complications and perhaps damage to neural tissues. Only scarce controlled data exist to determine when and what type of corticosteroids and the treatment regime to use. This article revisits the mechanisms of action, rationale, evidence of benefit, safety and problems of corticosteroids in the context of neurocysticercosis, as well as alternative anti-inflammatory strategies to limit the damage caused by inflammation in the CNS.

Indexed as

Adrenal Cortex HormonesAnimalsAnthelminticsAnti-Inflammatory AgentsCentral Nervous SystemHumansNeurocysticercosisTaenia soliumAdrenal Cortex HormonesAnthelminticsAnti-Inflammatory Agents

Identifiers

PMID21797658
PMCPMC3721198
OpenAlexW2033573591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.