ArticlePhysical review letters2011
Cell surface as a fractal: normal and cancerous cervical cells demonstrate different fractal behavior of surface adhesion maps at the nanoscale.
Article in Physical review letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 91 citations in OpenAlex.
- Detection of Human Bladder Epithelial Cancerous Cells with Atomic Force Microscopy and Machine Learning.Cells · 2024Article
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- Morphology of Neutrophils during Their Activation and NETosis: Atomic Force Microscopy Study.Cells · 2023Article
- Morphological profiling by high-throughput single-cell biophysical fractometry.Communications biology · 2023Article
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- Acceleration of imaging in atomic force microscopy working in sub-resonance tapping mode.The Review of scientific instruments · 2022Article
- Reversible capturing and voltammetric determination of circulating tumor cells using two-dimensional nanozyme based on PdMo decorated with gold nanoparticles and aptamer.Mikrochimica acta · 2021Article
- Impact of isolation methods on the biophysical heterogeneity of single extracellular vesicles.Scientific reports · 2020Article
- Calibration of T-shaped atomic force microscope cantilevers using the thermal noise method.The Review of scientific instruments · 2020Article
- Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish.Journal of the mechanical behavior of biomedical materials · 2020Article
- New Features for Neuron Classification.Neuroinformatics · 2019Article
- Noninvasive diagnostic imaging using machine-learning analysis of nanoresolution images of cell surfaces: Detection of bladder cancer.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Nanoscale compositional mapping of cells, tissues, and polymers with ringing mode of atomic force microscopy.Scientific reports · 2017Article
- Biophysical differences between chronic myelogenous leukemic quiescent and proliferating stem/progenitor cells.Nanomedicine : nanotechnology, biology, and medicine · 2016Article
- Towards early detection of cervical cancer: Fractal dimension of AFM images of human cervical epithelial cells at different stages of progression to cancer.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- Emerging of fractal geometry on surface of human cervical epithelial cells during progression towards cancer.New journal of physics · 2015Article
- Intercellular Signaling in Cancer-the SMT and TOFT Hypotheses, Exosomes, Telocytes and Metastases: Is the Messenger in the Message?Journal of Cancer · 2015Review
- The softening of human bladder cancer cells happens at an early stage of the malignancy process.Beilstein journal of nanotechnology · 2014Article
- Quantitative study of the elastic modulus of loosely attached cells in AFM indentation experiments.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Here we show that the surface of human cervical epithelial cells demonstrates substantially different fractal behavior when the cell becomes cancerous. Analyzing the adhesion maps of individual cervical cells, which were obtained using the atomic force microscopy operating in the HarmoniX mode, we found that cancerous cells demonstrate simple fractal behavior, whereas normal cells can only be approximated at best as multifractal. Tested on ~300 cells collected from 12 humans, the fractal dimensionality of cancerous cells is found to be unambiguously higher than that for normal cells.
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Registered trials
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