ArticleInternational journal of cancer2012
Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Implications of Heterotypic Cell Fusion in Cancer.Advances in experimental medicine and biology · 2026Review
- Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma.Journal of neuroinflammation · 2022Review
- Review
- Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.Journal of Cancer · 2022Review
- Cell Fusion-Related Proteins and Signaling Pathways, and Their Roles in the Development and Progression of Cancer.Frontiers in cell and developmental biology · 2021Review
- ELAVL1 Role in Cell Fusion and Tunneling Membrane Nanotube Formations with Implication to Treat Glioma Heterogeneity.Cancers · 2020Review
- Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Tumor Microenvironment and Cell Fusion.BioMed research international · 2019Review
- Kinin-B1 Receptor Stimulation Promotes Invasion and is Involved in Cell-Cell Interaction of Co-Cultured Glioblastoma and Mesenchymal Stem Cells.Scientific reports · 2018Article
- Cell-cell fusion as a mechanism of DNA exchange in cancer.Oncotarget · 2018Article
- Hypothesis: Cancer Is a Disease of Evolved Trade-Offs Between Neoplastic Virulence and Transmission.Journal of Cancer · 2018Review
- The Dark Side of Cell Fusion.International journal of molecular sciences · 2016Review
- Experimental research of host macrophage canceration induced by glioma stem progenitor cells.Molecular medicine reports · 2015Article
- Extracellular Vesicle-Mediated Reversal of Paclitaxel Resistance in Prostate Cancer.Critical reviews in oncogenesis · 2015Review
- Transfer of malignant trait to immortalized human cells following exposure to human cancer serum.Journal of experimental & clinical cancer research : CR · 2014Article
- Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer.Chinese journal of cancer · 2014Review
- The role of pleomorphic adenoma gene-like 2 in gastrointestinal cancer development, progression, and prognosis.International journal of clinical and experimental pathology · 2014Article
- Human pontine glioma cells can induce murine tumors.Acta neuropathologica · 2014Article
- In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA.PloS one · 2014Article
- Just like the rest of evolution in Mother Nature, the evolution of cancers may be driven by natural selection, and not by haphazard mutations.Oncoscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Cell fusion in vitro has been used to study cancer, gene mapping and regulation, and the production of antibodies via hybridomas. However, in-vivo heterosynkaryon formation by cell-cell fusion has received less attention. This investigation describes the spontaneous fusion of a human glioblastoma with normal hamster cells after xenogeneic transplantation, resulting in malignant cells that express both human and hamster genes and gene products, and retention of glioblastoma traits with an enhanced ability to metastasize. Three of 7 human genes found showed translation of their proteins during serial propagation in vivo or in vitro for years; namely, CD74, CXCR4 and PLAGL2, each implicated with malignancy or glioblastoma. This supports the thesis that genetic hybridization of cancer and normal cells can transmit malignancy and also, as first described herein, regulatory genes involved in the tumor's organotypic morphology. Evidence also is increasing that even cell-free human cancer DNA can induce malignancy and transfer genetic information to normal cells. Hence, we posit that the transfer of genetic information between tumor and stromal cells, whether by cell-cell fusion or other mechanisms, is implicated in the progression of malignancy, and may further define the crosstalk between cancer cells and their stromal neighbors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.