Evidence map›Paper›PMID 21796513›Full record

ReviewCurrent topics in microbiology and immunology2012

Editing of neurotransmitter receptor and ion channel RNAs in the nervous system.

Jennifer L Hood, Ronald B Emeson

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Unique signatures of highly constrained genes across publicly available genomic databases.Genetics in medicine : official journal of the American College of Medical Genetics · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Endogenous Double-Stranded RNA.Non-coding RNA · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer L HoodTraining Program in Cellular and Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, USA.
Ronald B Emeson
Vanderbilt University · US

Funding

Project 6 Interactions of Serotonin and Circadian Signaling NetworksP50MH078028 · NIMH · VANDERBILT UNIVERSITY · PI SNODDY, JAY R · 2007 to 2011
$9.8M
Training in Fundamental NeuroscienceT32MH064913 · NIMH · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A, WINDER, DANNY G. · 2001 to 2022
$7.6M
REGULATION OF RNA EDITING IN THE CNSR01NS033323 · NINDS · VANDERBILT UNIVERSITY · PI EMESON, RONALD B. · 1995 to 2010
$2.5M
NIMH NIH HHS P50 MH078028NIMH NIH HHS T32 MH064913NINDS NIH HHS R01 NS033323
6 · The paper itself

Abstract

The central dogma of molecular biology defines the major route for the transfer of genetic information from genomic DNA to messenger RNA to three-dimensional proteins that affect structure and function. Like alternative splicing, the post-transcriptional conversion of adenosine to inosine (A-to-I) by RNA editing can dramatically expand the diversity of the transcriptome to generate multiple, functionally distinct protein isoforms from a single genomic locus. While RNA editing has been identified in virtually all tissues, such post-transcriptional modifications have been best characterized in RNAs encoding both ligand- and voltage-gated ion channels and neurotransmitter receptors. These RNA processing events have been shown to play an important role in the function of the encoded protein products and, in several cases, have been shown to be critical for the normal development and function of the nervous system.

Indexed as

RNA EditingAdenosine DeaminaseAmino Acid SequenceIon ChannelsKainic Acid ReceptorsMolecular Sequence DataNervous SystemReceptors, AMPAReceptor, Serotonin, 5-HT2CReceptors, GABA-AReceptors, NeurotransmitterRNA-Binding ProteinsADARB1 protein, humanAdenosine DeaminaseIon ChannelsKainic Acid ReceptorsReceptors, AMPAReceptor, Serotonin, 5-HT2CReceptors, GABA-AReceptors, NeurotransmitterRNA-Binding Proteins

Identifiers

PMID21796513
PMCPMC4109139
OpenAlexW1485858386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.