ArticleClinical research in cardiology : official journal of the German Cardiac Society2011
Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 174 citations in OpenAlex.
- The role of intravascular imaging in optimizing renal denervation outcomes.Cardiology journal · 2026Review
- Engineered Liposomal Delivery ofPharmaceutics · 2025Article
- Mice Models for Peripheral Denervation to Enhance Vascular Regeneration.Tissue engineering. Part C, Methods · 2025Article
- Renal Denervation as a Complementary Treatment Option for Uncontrolled Arterial Hypertension: A Situation Assessment.Journal of clinical medicine · 2023Review
- Renal denervation in patients with chronic kidney disease: current evidence and future perspectives.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Review
- 2022 Renal denervation therapy for the treatment of hypertension: a statement from the Thai Hypertension Society.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Article
- Renal Sympathetic Denervation for Hypertension.Kidney international reports · 2022Review
- Renal Denervation for Patients With Atrial Fibrillation.Current cardiology reports · 2021Review
- Renal Denervation to Treat Heart Failure.Annual review of physiology · 2021Review
- Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies.Animals : an open access journal from MDPI · 2020Article
- 2019 Consensus Statement of the Taiwan Hypertension Society and the Taiwan Society of Cardiology on Renal Denervation for the Management of Arterial Hypertension.Acta Cardiologica Sinica · 2019Review
- Acute changes in morphology and renal vascular relaxation function after renal denervation using temperature-controlled radiofrequency catheter.BMC cardiovascular disorders · 2019Article
- Safety of catheter-based radiofrequency renal denervation on branch renal arteries in a porcine model.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2019Article
- The effect of renal denervation in an experimental model of chronic renal insufficiency, The REmnant kidney Denervation In Pigs study (REDIP study).Journal of translational medicine · 2017Article
- Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model.Journal of cardiovascular translational research · 2017Article
- Renal Artery Vasodilation May Be An Indicator of Successful Sympathetic Nerve Damage During Renal Denervation Procedure.Scientific reports · 2016Article
- Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings.International journal of cardiology. Heart & vasculature · 2016Article
- Renal artery sympathetic denervation: observations from the UK experience.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Long-term follow-up of renal arteries after radio-frequency catheter-based denervation using optical coherence tomography and angiography.The international journal of cardiovascular imaging · 2016Observational
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal sympathetic hyperactivity is associated with hypertension, a leading cause of mortality worldwide. Renal sympathetic denervation via the Symplicity Catheter System has been shown to decrease blood pressure by 33/11 mmHg by 6 months, with no radiofrequency (RF)-related adverse sequelae visible by CT/MR angiography or renal duplex ultrasound 6 months after the procedure. Here, we present preclinical work predating those clinical results. We performed therapeutic renal sympathetic denervation in a swine animal model to characterize the vascular safety and healing response 6 months after renal denervation therapy.
methodsIn December 2007, seven domestic swine received a total of 32 radiofrequency ablations via the Symplicity Catheter System and were euthanatized 6 months later. Renal angiography was done before, immediately after, and 6 months after procedure. The renal vessels were examined histologically with H&E and Movat pentachrome stains to identify evidence of vascular and neural injury. The kidneys and urinary system were also examined for evidence of gross and microscopic abnormalities.
resultsRenal nerve injury involved primarily nerve fibrosis, replacement of nerve fascicles with fibrous connective tissue, and thickening of the epineurium and perineurium. Renal arterial findings included fibrosis of 10-25% of the total media and underlying adventitia, with mild disruption of the external elastic lamina. No significant smooth muscle hyperplasia or inflammatory components were observed. There was no renal arterial stenosis or thrombosis observed by angiography or histology. No gross or microscopic device-related abnormalities were noted in the kidney, surrounding stroma, or urinary bladder.
conclusionsIn a swine model, renal denervation via the Symplicity Catheter System resulted in no clinically significant adverse renal artery or renal findings 6 months after the procedure. This is corroborated by the vascular safety profile demonstrated in subsequent human clinical studies.
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