ArticleAmerican journal of cancer research2011
MicroRNA analysis of microdissected normal squamous esophageal epithelium and tumor cells.
Article in American journal of cancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets.Cancer biomarkers : section A of Disease markers · 2023Pooled it
- Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and gastrointestinal cancer risk.Molecular biology reports · 2013Pooled it
- A myriad of roles of miR-25 in health and disease.Oncotarget · 2018Review
- miR-25 is upregulated before the occurrence of esophageal squamous cell carcinoma.American journal of translational research · 2017Article
- MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency.Oncotarget · 2016Article
- Differential expression of miR-21 and miR-75 in esophageal carcinoma patients and its clinical implication.American journal of translational research · 2016Article
- MicroRNA-135b regulates apoptosis and chemoresistance in colorectal cancer by targeting large tumor suppressor kinase 2.American journal of cancer research · 2015Article
- Pediatric eosinophilic esophagitis is associated with changes in esophageal microRNAs.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Plasma microRNA profiles: identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma.British journal of cancer · 2014Article
- MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways.Journal of cellular and molecular medicine · 2014Review
- Tissue slide-based microRNA characterization of tumors: how detailed could diagnosis become for cancer medicine?Expert review of molecular diagnostics · 2014Review
- Inhibition of microRNA-21 upregulates the expression of programmed cell death 4 and phosphatase tensin homologue in the A431 squamous cell carcinoma cell line.Oncology letters · 2014Article
- Circulatory miR-628-5p is downregulated in prostate cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Article
- Depleting ABCE1 expression induces apoptosis and inhibits the ability of proliferation and migration of human esophageal carcinoma cells.International journal of clinical and experimental pathology · 2014Article
- Beyond laser microdissection technology: follow the yellow brick road for cancer research.American journal of cancer research · 2014Review
- MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor.PloS one · 2013Article
- Article
- miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.Anesthesiology · 2012Article
- MicroRNAs in cancer treatment and prognosis.American journal of cancer research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Previous studies have identified several dysregulated microRNAs in esophageal squamous cell carcinoma (ESCC); however, to date there are no ex vivo analyses comparing expression levels of these regulatory molecules in esophageal squamous cell tumors versus patient-matched normal epithelium. We describe here a technical strategy to evaluate microRNAs in normal esophageal basal cells (NB), normal esophageal differentiated cells (ND), and tumor cells (T). Laser capture microdissection was used to procure target populations from five cases and 18 ESCC-associated microRNAs were measured by RT-qPCR. Five microRNAs (miR-25, miR-106b, miR-21, miR-203, and miR-145) demonstrated consistent differential expression in at least one of the three comparisons: T vs. NB, T vs. ND, or NB vs. ND. The potential regulatory role of the microRNAs in ESCC was further evaluated by correlating their expression with a matched mRNA dataset, which included the same five cases and cell populations. In conclusion, the present work demonstrates the feasibility of studying microRNA levels in precisely dissected cell populations from clinical samples, and sheds light on the molecular mechanisms associated with ESCC.
Identifiers
21796275PMC3142940What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.