ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Acute nicotine-induced tachyphylaxis is differentially manifest in the limbic system.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
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- Randomized clinical trial of low dose suramin intravenous infusions for treatment of autism spectrum disorder.Annals of general psychiatry · 2023Article
- Evidence of Altered Brain Responses to Nicotine in an Animal Model of Attention Deficit/Hyperactivity Disorder.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Effect of Abstinence on Audio-Visual Reaction Time in Chronic Smokers Pursuing a Professional Course.Journal of clinical and diagnostic research : JCDR · 2015Article
- Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats.The international journal of neuropsychopharmacology · 2014Article
- Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure.Reviews in the neurosciences · 2014Review
- Rapid sensitization of physiological, neuronal, and locomotor effects of nicotine: critical role of peripheral drug actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
Rapid tolerance develops to many of nicotine's behavioral and autonomic effects. A better understanding of the spatiotemporal patterns in neuronal activity as a consequence of acute nicotine tolerance (tachyphylaxis) may help explain its commonly found inverted 'U'-shaped biphasic dose-effect relationship on various behaviors. To this end, we employed high-resolution functional magnetic resonance imaging and relative cerebral blood volume (rCBV) as a marker of neuronal activity, to characterize the regional development of acute tolerance as a function of nicotine dose in naïve, anesthetized rats. A single intravenous nicotine injection at 0.1 and 0.3, but not 0.03 mg/kg, significantly increased neuronal activity in many neocortical areas. In contrast, dose-dependent increases in rCBV were most pronounced in limbic regions, such that responses seen at 0.1 mg/kg nicotine in accumbens, hippocampus, amygdala, and several other limbic areas were not seen following 0.3 mg/kg nicotine. Finally, whereas profound tolerance was observed in many cortical regions after the second of two paired nicotine injections at either 0.1 or 0.3 mg/kg, subcortical limbic structures showed only a weak trend for tolerance. Lack of rCBV changes in animals receiving nicotine methiodide, a quaternary nicotine analog that does not cross the blood-brain barrier, supports a direct neuronal effect of nicotine rather than an action on the vasculature. These data provide pharmacodynamic insight into the regional heterogeneity of nicotine tachyphylaxis development, which may be relevant to behavioral and neurobiological mechanisms associated with repeated tobacco consumption.
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