ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Social interaction promotes nicotine self-administration with olfactogustatory cues in adolescent rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Sex differences in nicotine intravenous self-administration: A meta-analytic review.Physiology & behavior · 2019Pooled it
- Article
- Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI.Molecular psychiatry · 2024Article
- Chemosensory Contributions of E-Cigarette Additives on Nicotine Use.Frontiers in neuroscience · 2022Review
- Oxytocin-induced anxiogenic behavior in juvenile male rats.Animal cells and systems · 2021Article
- History repeats itself: Role of characterizing flavors on nicotine use and abuse.Neuropharmacology · 2020Review
- Nicotine Self-Administration With Tobacco Flavor Additives in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- An insular view of the social decision-making network.Neuroscience and biobehavioral reviews · 2019Review
- Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats.Scientific reports · 2018Article
- A review of the effects of nicotine on social functioning.Experimental and clinical psychopharmacology · 2018Review
- Suppressive and enhancing effects of nicotine on food-seeking behavior.Behavioural brain research · 2018Article
- Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats.Scientific reports · 2017Article
- Differential effects of pair housing on voluntary nicotine consumption: a comparison between male and female adolescent rats.Psychopharmacology · 2017Article
- Social context has differential effects on acquisition of nicotine self-administration in male and female rats.Psychopharmacology · 2017Article
- The case for investigating social context in laboratory studies of smoking.Addiction (Abingdon, England) · 2017Review
- Immediate early gene expression reveals interactions between social and nicotine rewards on brain activity in adolescent male rats.Behavioural brain research · 2016Article
- Socially acquired nicotine self-administration with an aversive flavor cue in adolescent female rats.Psychopharmacology · 2016Article
- The Two Faces of Social Interaction Reward in Animal Models of Drug Dependence.Neurochemical research · 2016Review
- Animal models of social contact and drug self-administration.Pharmacology, biochemistry, and behavior · 2015Review
- Emergence of sex differences in the development of substance use and abuse during adolescence.Pharmacology & therapeutics · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cigarette smoking is a social behavior. Smoking is also accompanied by distinctive gustatory and olfactory stimulation. However, none of these factors affecting nicotine intake are modeled in existing preclinical studies. We report a novel model of adolescent nicotine self-administration (SA) in rats where licking on drinking spouts was used as the operant behavior to activate the concurrent delivery of nicotine (i.v.) and an appetitive olfactogustatory (OG) cue, and social interaction was required for stable SA. The operant chamber was divided by a panel that separated the SA rat and another rat serving as the demonstrator, who had free access to the OG cue but did not receive nicotine. Orofacial contacts were permitted by the divider. Conditioned taste aversion prevented solo rats to self-administer nicotine. However, stable nicotine (15-30 μg/kg, free base) SA was established in the presence of demonstrator rats with free access to the OG cue. Omitting the olfactory component of the cue prevented the acquisition of nicotine SA. Mecamylamine, a nicotinic antagonist, reduced licking behavior. Familiar peers were more effective demonstrators in facilitating the acquisition of nicotine SA than were unfamiliar rats. No sex difference in nicotine intake was found. These data indicate that the contingent OG cue is associated with the aversive property of nicotine that prevents subsequent drug intake. Social information encoded in olfaction not only permits the establishment of stable nicotine SA but also enhances nicotine intake. These findings implicate adolescent social interactions in promoting smoking behavior by surmounting the aversive property of nicotine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.