ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Pharmacogenetic association of the galanin receptor (GALR1) SNP rs2717162 with smoking cessation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- SNP analysis of stress-related genes reveals significant correlations with drug addiction in Jordan.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Article
- Identification of candidate genes for nicotine withdrawal in C57BL/6J × DBA/2J recombinant inbred mice.Genes, brain, and behavior · 2023Article
- Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice.Frontiers in genetics · 2021Article
- Neuropeptide systems and new treatments for nicotine addiction.Psychopharmacology · 2017Review
- Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.Brain research · 2016Review
- Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.Alcoholism, clinical and experimental research · 2016Article
- New mechanisms and perspectives in nicotine withdrawal.Neuropharmacology · 2015Review
- The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex.Addiction biology · 2015Article
- Inhibition of monoacylglycerol lipase reduces nicotine withdrawal.British journal of pharmacology · 2015Article
- Brain galanin system genes interact with life stresses in depression-related phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Alteration of behavioral changes and hippocampus galanin expression in chronic unpredictable mild stress-induced depression rats and effect of electroacupuncture treatment.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice.Psychopharmacology · 2013Article
- A high-fat diet or galanin in the PVN decreases phosphorylation of CREB in the nucleus accumbens.Neuroscience · 2013Article
- Chronic nicotine treatment impacts the regulation of opioid and non-opioid peptides in the rat dorsal striatum.Molecular & cellular proteomics : MCP · 2013Article
- Distinct features of neurotransmitter systems in the human brain with focus on the galanin system in locus coeruleus and dorsal raphe.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Galnon facilitates extinction of morphine-conditioned place preference but also potentiates the consolidation process.PloS one · 2013Article
- Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking.OncoTargets and therapy · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The neuropeptide galanin and its receptors are expressed in brain regions implicated in drug dependence. Indeed, several lines of evidence support a role for galanin in modulating the effects of drugs of abuse, including morphine, cocaine, amphetamine, and alcohol. Despite these findings, the role of galanin and its receptors in the effects of nicotine is largely underexplored. Here, using mouse models of nicotine reward and withdrawal, we show that there is a significant correlation between mecamylamine-precipitated nicotine withdrawal somatic signs and basal galanin or galanin receptor 1 (GALR1) expression in mesolimbocortical dopamine regions across the BXD battery of recombinant inbred mouse lines. The non-peptide galanin receptor agonist, galnon, also blocks nicotine rewarding effects and reverses mecamylamine-precipitated nicotine withdrawal signs in ICR mice. Additionally, we conducted a meta-analysis using smoking information from six European-American and African-American data sets. In support of our animal data, results from the association study show that variants in the GALR1 gene are associated with a protective effect in nicotine dependence (ND). Taken together, our data suggest that galanin has a protective role against progression to ND, and these effects may be mediated through GALR1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.