ArticlePediatric research2011
Risk factors for epilepsy in children with neonatal encephalopathy.
Article in Pediatric research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Prevalence, characteristics, and treatment outcomes of epilepsy in Nigeria: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Optical Monitoring in Neonatal Seizures.Cells · 2022Pooled it
- Post-neonatal epilepsy in newborns with neurologic conditions: a retrospective cohort study from a tertiary center.Pediatric research · 2026Article
- Mechanistically informed circulating biomarkers are associated with acquired epilepsy after neonatal brain injury.Journal of neuroinflammation · 2026Observational
- The relationship between low birth weight and neurological disorders: a prospective cohort study in the UK Biobank.BMC neurology · 2026Article
- Predictors of Drug-Resistant Epilepsy After Perinatal Stroke.Pediatric neurology · 2026Observational
- The risk of epilepsy after neonatal seizures.Developmental medicine and child neurology · 2025Article
- Short-horizon neonatal seizure prediction using EEG-based deep learning.PLOS digital health · 2025Article
- Machine learning for forecasting initial seizure onset in neonatal hypoxic-ischemic encephalopathy.Epilepsia · 2025Article
- The future is in the background: background EEG patterns, not acute seizures, predict epilepsy and neurodevelopmental outcomes in neonatal HIE.Frontiers in pediatrics · 2025Article
- Neonatal brain MRI and short-term outcomes after acute provoked seizures.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Antiseizure medication at discharge in infants with hypoxic-ischaemic encephalopathy: an observational study.Archives of disease in childhood. Fetal and neonatal edition · 2023Observational
- Early Discontinuation of Phenobarbital After Acute Symptomatic Neonatal Seizures in the Term Newborn.Neurology. Clinical practice · 2023Article
- Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial.Annals of the Child Neurology Society · 2023Article
- Brain temperature monitoring in newborn infants: Current methodologies and prospects.Frontiers in pediatrics · 2022Review
- Article
- Deficits in Seizure Threshold and Other Behaviors in Adult Mice without Gross Neuroanatomic Injury after Late Gestation Transient Prenatal Hypoxia.Developmental neuroscience · 2022Article
- Effectiveness of vagus nerve stimulation therapy in refractory hypoxic-ischemic encephalopathy-induced epilepsy.Therapeutic advances in neurological disorders · 2022Article
- Article
- Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap.Nature reviews. Neurology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
We examined neonatal predictors of epilepsy in term newborns with neonatal encephalopathy (NE) by studying children enrolled in a longitudinal, single center cohort study. Clinical data were obtained through chart review, and MRI was performed in the neonatal period. We administered a seizure questionnaire to parents of children aged ≥ 12 mo (range, 12 mo to 16.5 y) to determine the outcome of epilepsy. The association between clinical predictors and time to onset of epilepsy was assessed using Cox proportional hazards regression. Thirteen of 129 children developed epilepsy: all had neonatal seizures and brain injury on neonatal MRI. Of the newborns with neonatal seizures, 25% (15.8/1000 person-years) developed epilepsy, with the highest hazard ratios (HRs) in the newborns with status epilepticus (HR, 35.8; 95% CI, 6.5-196.5). Children with severe or near-total brain injury were more likely to develop epilepsy compared with those with only mild or moderate injury (HR, 5.5; 95% CI, 1.8-16.8). In a multivariable analysis adjusting for degree of encephalopathy and severe/near-total brain injury, status epilepticus was independently associated with epilepsy. These data add to information regarding epilepsy pathogenesis and further aid clinicians to counsel parents regarding the likelihood that a newborn with NE will develop epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.