ArticleThe Journal of biological chemistry2011
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.BMC biology · 2023Article
- SPOP regulates the expression profiles and alternative splicing events in human hepatocytes.Open life sciences · 2023Article
- MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes.Journal of biochemistry · 2022Article
- Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer.Molecular oncology · 2020Article
- RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis.Cell death & disease · 2018Article
- Autophagy-monitoring and autophagy-deficient mice.Autophagy · 2017Review
- ZEB1-regulated inflammatory phenotype in breast cancer cells.Molecular oncology · 2017Article
- Regulation of TGF-β Family Signaling by Inhibitory Smads.Cold Spring Harbor perspectives in biology · 2017Review
- RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.Oncogene · 2016Article
- Atg13 Is Essential for Autophagy and Cardiac Development in Mice.Molecular and cellular biology · 2016Article
- c-Jun N-terminal kinase inhibitor favors transforming growth factor-β to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellular carcinoma.Molecular medicine reports · 2016Article
- Autophagy signal transduction by ATG proteins: from hierarchies to networks.Cellular and molecular life sciences : CMLS · 2015Review
- A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.Cell research · 2014Article
- Robo1 modulates proliferation and neurogenesis in the developing neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination.Oncogene · 2013Article
- RNF111-dependent neddylation activates DNA damage-induced ubiquitination.Molecular cell · 2013Article
- Review
- Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.PLoS biology · 2013Article
- Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.The EMBO journal · 2012Article
- Regulation of the transforming growth factor β pathway by reversible ubiquitylation.Open biology · 2012Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor-β (TGF-β) signaling is controlled by a variety of regulators, of which Smad7, c-Ski, and SnoN play a pivotal role in its negative regulation. Arkadia is a RING-type E3 ubiquitin ligase that targets these negative regulators for degradation to enhance TGF-β signaling. In the present study we identified a candidate human tumor suppressor gene product RB1CC1/FIP200 as a novel positive regulator of TGF-β signaling that functions as a substrate-selective cofactor of Arkadia. Overexpression of RB1CC1 enhanced TGF-β signaling, and knockdown of endogenous RB1CC1 attenuated TGF-β-induced expression of target genes as well as TGF-β-induced cytostasis. RB1CC1 down-regulated the protein levels of c-Ski but not SnoN by enhancing the activity of Arkadia E3 ligase toward c-Ski. Substrate selectivity is primarily attributable to the physical interaction of RB1CC1 with substrates, suggesting its role as a scaffold protein. RB1CC1 thus appears to play a unique role as a modulator of TGF-β signaling by restricting substrate specificity of Arkadia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.