Evidence map›Paper›PMID 21795587›Full record

Trial reportScience translational medicine2011

Photoactivated composite biomaterial for soft tissue restoration in rodents and in humans.

Alexander T Hillel, Shimon Unterman, Zayna Nahas, Branden Reid, Jeannine M Coburn, Joyce Axelman, Jemin J Chae, Qiongyu Guo, Robert Trow, Andrew Thomas and 9 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Science translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 106 citations in OpenAlex.

  1. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Matrix stiffness primes lymphatic tube formation directed by vascular endothelial growth factor-C.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  15. Review
  16. Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery.International journal of molecular sciences · 2020
    Review
  17. Article
  18. Article
  19. Article
  20. Biomaterials for tissue repair.Science (New York, N.Y.) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Alexander T Hillel *Department of Otolaryngology, Johns Hopkins University, Baltimore, MD 21287, USA.
Shimon Unterman *Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Zayna NahasDepartment of Ophthalmology, Stanford University, Palo Alto, CA 94305, USA.
Branden ReidTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Jeannine M CoburnDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Joyce AxelmanTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Jemin J ChaeTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Qiongyu GuoTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Robert TrowEnergist North America, Nyack, NY 10960, USA.
Andrew ThomasEnergist North America, Nyack, NY 10960, USA.
Zhipeng HouDepartment of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA.
Serge LichtsteinerKythera Biopharmaceuticals, Calabasas, CA 91301, USA.
Damon SuttonKythera Biopharmaceuticals, Calabasas, CA 91301, USA.
Christine MathesonKythera Biopharmaceuticals, Calabasas, CA 91301, USA.
Patricia WalkerKythera Biopharmaceuticals, Calabasas, CA 91301, USA.
Nathaniel DavidKythera Biopharmaceuticals, Calabasas, CA 91301, USA.
Susumu MoriDepartment of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA.
Janis M TaubeDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Johns Hopkins University · USStanford University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Chondroitin sulfate-fiber hydrogels for cartilage tissue engineeringF31AG033999 · NIA · JOHNS HOPKINS UNIVERSITY · PI COBURN, JEANNINE · 2009 to 2012
$102k
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

Soft tissue reconstruction often requires multiple surgical procedures that can result in scars and disfiguration. Facial soft tissue reconstruction represents a clinical challenge because even subtle deformities can severely affect an individual's social and psychological function. We therefore developed a biosynthetic soft tissue replacement composed of poly(ethylene glycol) (PEG) and hyaluronic acid (HA) that can be injected and photocrosslinked in situ with transdermal light exposure. Modulating the ratio of synthetic to biological polymer allowed us to tune implant elasticity and volume persistence. In a small-animal model, implanted photocrosslinked PEG-HA showed a dose-dependent relationship between increasing PEG concentration and enhanced implant volume persistence. In direct comparison with commercial HA injections, the PEG-HA implants maintained significantly greater average volumes and heights. Reversibility of the implant volume was achieved with hyaluronidase injection. Pilot clinical testing in human patients confirmed the feasibility of the transdermal photocrosslinking approach for implantation in abdomen soft tissue, although an inflammatory response was observed surrounding some of the materials.

Indexed as

LightAnimalsBiocompatible MaterialsCollagen Type ICross-Linking ReagentsDermisHumansHyaluronic AcidImplants, ExperimentalMaterials TestingOrgan SpecificityPilot ProjectsPolyethylene GlycolsRatsRheologyTissue EngineeringBiocompatible MaterialsCollagen Type ICross-Linking ReagentsHyaluronic AcidPolyethylene Glycols

Identifiers

PMID21795587
PMCPMC4652657
OpenAlexW1969640372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.