Evidence map›Paper›PMID 21795553›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2011

Repetitive transcranial magnetic stimulation enhances BDNF-TrkB signaling in both brain and lymphocyte.

Hoau-Yan Wang, Domenica Crupi, Jingjing Liu, Andres Stucky, Giuseppe Cruciata, Alessandro Di Rocco, Eitan Friedman, Angelo Quartarone, M Felice Ghilardi

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 7 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 7 syntheses or guidelines pooled it, 213 citations in OpenAlex.

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  7. Effects of non-invasive brain stimulation on post-stroke dysphagia: A systematic review and meta-analysis of randomized controlled trials.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hoau-Yan WangDepartment of Physiology, Pharmacology & Neuroscience, Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA. hywang@sci.ccny.cuny.edu
Domenica Crupi
Jingjing Liu
Andres Stucky
Giuseppe Cruciata
Alessandro Di Rocco
Eitan Friedman
Angelo Quartarone
M Felice Ghilardi
City University of New York · USUniversity of Messina · IT

Funding

MIDARP at CCNYR24DA018055 · NIDA · CITY COLLEGE OF NEW YORK · PI FRIEDMAN, EITAN · 2005 to 2010
$2.2M
Consolidation of Motor Skills & Sleep Homeostasis in Parkinson's DiseaseR01NS054864 · NINDS · CITY COLLEGE OF NEW YORK · PI GHILARDI, M. FELICE MARINA · 2007 to 2011
$1.8M
NIDA NIH HHS R24 DA018055NIDA NIH HHS R24-DA018055NINDS NIH HHS R01 NS054864PHS HHS R01-054864
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) induces neuronal long-term potentiation or depression. Although brain-derived neurotrophic factor (BDNF) and its cognate tyrosine receptor kinase B (TrkB) contribute to the effects of rTMS, their precise role and underlying mechanism remain poorly understood. Here we show that daily 5 Hz rTMS for 5 d improves BDNF-TrkB signaling in rats by increasing the affinity of BDNF for TrkB, which results in higher tyrosine-phosphorylated TrkB, increased recruitment of PLC-γ1 and shc/N-shc to TrkB, and heightened downstream ERK2 and PI-3K activities in prefrontal cortex and in lymphocytes. The elevated BDNF-TrkB signaling is accompanied by an increased association between the activated TrkB and NMDA receptor (NMDAR). In normal human subjects, 5 d rTMS to motor cortex decreased resting motor threshold, which correlates with heightened BDNF-TrkB signaling and intensified TrkB-NMDAR association in lymphocytes. These findings suggest that rTMS to cortex facilitates BDNF-TrkB-NMDAR functioning in both cortex and lymphocytes.

Indexed as

Transcranial Magnetic StimulationAdultAnalysis of VarianceAnimalsBrainBrain-Derived Neurotrophic FactorCross-Over StudiesDouble-Blind MethodElectromyographyEvoked Potentials, MotorFemaleGene Expression RegulationHumansIn Vitro TechniquesLymphocytesMaleBrain-Derived Neurotrophic FactorReceptors, N-Methyl-D-AspartateReceptor, trkB

Identifiers

PMID21795553
PMCPMC3161730
OpenAlexW1999522424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.