ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Synaptic kainate receptors in interplay with INaP shift the sparse firing of dentate granule cells to a sustained rhythmic mode in temporal lobe epilepsy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 53 citations in OpenAlex.
- Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.iScience · 2022Article
- Alterations of Neuronal Dynamics as a Mechanism for Cognitive Impairment in Epilepsy.Current topics in behavioral neurosciences · 2022Review
- Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- Impact of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Kainate Receptors: Role in Epilepsy.Frontiers in molecular neuroscience · 2018Review
- Position- and Time-DependentFrontiers in cellular neuroscience · 2018Article
- Short-Term Depression of Sprouted Mossy Fiber Synapses from Adult-Born Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Normal and epilepsy-associated pathologic function of the dentate gyrus.Progress in brain research · 2016Review
- Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing.Journal of neurophysiology · 2015Article
- Detrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy.Frontiers in cellular neuroscience · 2015Article
- Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression.Metabolic brain disease · 2014Article
- The information content of physiological and epileptic brain activity.The Journal of physiology · 2013Review
- Phenytoin inhibits the persistent sodium current in neocortical neurons by modifying its inactivation properties.PloS one · 2013Article
- Article
- Reactive plasticity with a kainate receptor twist: rhythmic firing in granule cells breaks down the gate?Epilepsy currents · 2012Article
- Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Dentate granule cells, at the gate of the hippocampus, use coincidence detection of synaptic inputs to code afferent information under a sparse firing regime. In both human patients and animal models of temporal lobe epilepsy, mossy fibers sprout to form an aberrant glutamatergic network between dentate granule cells. These new synapses operate via long-lasting kainate receptor-mediated events, which are not present in the naive condition. Here, we report that in chronic epileptic rat, aberrant kainate receptors in interplay with the persistent sodium current dramatically expand the temporal window for synaptic integration. This introduces a multiplicative gain change in the input-output operation of dentate granule cells. As a result, their sparse firing is switched to an abnormal sustained and rhythmic mode. We conclude that synaptic kainate receptors dramatically alter the fundamental coding properties of dentate granule cells in temporal lobe epilepsy.
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