ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2011
Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Association between 1p11-rs11249433 polymorphism and breast cancer susceptibility: evidence from 15 case-control studies.PloS one · 2013Pooled it
- Quantitative assessment of common genetic variants on chromosome 5p12 and hormone receptor status with breast cancer risk.PloS one · 2013Pooled it
- Association between 5p12 genomic markers and breast cancer susceptibility: evidence from 19 case-control studies.PloS one · 2013Pooled it
- The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.Molecular oncology · 2014Trial
- Common variants in breast cancer risk loci predispose to distinct tumor subtypes.Breast cancer research : BCR · 2022Article
- circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma.Journal of experimental & clinical cancer research : CR · 2021Article
- A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium.International journal of cancer · 2018Article
- Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.American journal of human genetics · 2016Article
- Genetic predisposition to ductal carcinoma in situ of the breast.Breast cancer research : BCR · 2016Article
- Genetic risk variants associated with in situ breast cancer.Breast cancer research : BCR · 2015Article
- A robust association test for detecting genetic variants with heterogeneous effects.Biostatistics (Oxford, England) · 2015Article
- Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.Human molecular genetics · 2014Article
- Reproductive windows, genetic loci, and breast cancer risk.Annals of epidemiology · 2014Article
- Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.Carcinogenesis · 2014Article
- Genetic predisposition to in situ and invasive lobular carcinoma of the breast.PLoS genetics · 2014Article
- A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.Human molecular genetics · 2014Article
- Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach.American journal of epidemiology · 2014Article
- Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer.British journal of cancer · 2013Article
- Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes.PloS one · 2013Article
- Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.PLoS genetics · 2013Article
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Authors and funding
146 authors at 2 institutions in 7 countries.
Funding
Abstract
backgroundThe single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium.
methodsData were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression.
resultsFor white Europeans, the per-allele OR associated with 5p12-rs10941679 was 1.11 (95% CI = 1.08-1.14, P = 7 × 10(-18)) for invasive breast cancer and 1.10 (95% CI = 1.01-1.21, P = 0.03) for DCIS. For Asian women, the estimated OR for invasive disease was similar (OR = 1.07, 95%CI = 0.99-1.15, P = 0.09). Further analyses suggested that the association in white Europeans was largely limited to progesterone receptor (PR)-positive disease (per-allele OR = 1.16, 95% CI = 1.12-1.20, P = 1 × 10(-18) vs. OR = 1.03, 95% CI = 0.99-1.07, P = 0.2 for PR-negative disease; P(heterogeneity) = 2 × 10(-7)); heterogeneity by ER status was not observed (P = 0.2) once PR status was accounted for. The association was also stronger for lower grade tumors [per-allele OR (95% CI) = 1.20 (1.14-1.25), 1.13 (1.09-1.16), and 1.04 (0.99-1.08) for grade 1, 2, and 3/4, respectively; P(trend) = 5 × 10(-7)].
conclusion5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer. IMPACT: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants.
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