ArticleMolecular biology of the cell2011
The period of the somite segmentation clock is sensitive to Notch activity.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- A genetically encoded redox bottleneck constrains human developmental rate.bioRxiv : the preprint server for biology · 2026Article
- Genome-Wide Association Study of Rib Number and Total Thoracolumbar Vertebrae Number in a Jishen Black Pig Population.Veterinary sciences · 2026Article
- Trunk Muscle Differentiation and Growth in Vertebrates.Results and problems in cell differentiation · 2026Review
- Novel Splice Variant in theDiagnostics (Basel, Switzerland) · 2025Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- Spatiotemporal control of pattern formation during somitogenesis.Science advances · 2024Review
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- A novel homozygousFrontiers in pediatrics · 2023Article
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- Time and space in segmentation.Interface focus · 2021Article
- Proximity to the Promoter and Terminator Regions Regulates the Transcription Enhancement Potential of an Intron.Frontiers in molecular biosciences · 2021Article
- A tale of two clocks: phosphorylation of NICD by CDKs links cell cycle and segmentation clock.EMBO reports · 2019Article
- CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock.EMBO reports · 2019Article
- Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation.Development (Cambridge, England) · 2018Article
- Recent advances in understanding vertebrate segmentation.F1000Research · 2018Review
- Article
- Delta-Notch signalling in segmentation.Arthropod structure & development · 2017Review
- Faster embryonic segmentation through elevated Delta-Notch signalling.Nature communications · 2016Article
- Anabolic actions of Notch on mature bone.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Impaired cytoskeletal arrangements and failure of ventral body wall closure in chick embryos treated with rock inhibitor (Y-27632).Pediatric surgery international · 2016Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of vertebrae is defined strictly for a given species and depends on the number of somites, which are the earliest metameric structures that form in development. Somites are formed by sequential segmentation. The periodicity of somite segmentation is orchestrated by the synchronous oscillation of gene expression in the presomitic mesoderm (PSM), termed the "somite segmentation clock," in which Notch signaling plays a crucial role. Here we show that the clock period is sensitive to Notch activity, which is fine-tuned by its feedback regulator, Notch-regulated ankyrin repeat protein (Nrarp), and that Nrarp is essential for forming the proper number and morphology of axial skeleton components. Null-mutant mice for Nrarp have fewer vertebrae and have defective morphologies. Notch activity is enhanced in the PSM of the Nrarp(-/-) embryo, where the ~2-h segmentation period is extended by 5 min, thereby forming fewer somites and their resultant vertebrae. Reduced Notch activity partially rescues the Nrarp(-/-) phenotype in the number of somites, but not in morphology. Therefore we propose that the period of the somite segmentation clock is sensitive to Notch activity and that Nrarp plays essential roles in the morphology of vertebrae and ribs.
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