Evidence map›Paper›PMID 21795081›Full record

ReviewSleep medicine reviews2012

Epidemiology of restless legs syndrome: a synthesis of the literature.

Maurice M Ohayon, Ruth O'Hara, Michael V Vitiello

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sleep medicine reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 216 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 16 pooled it
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03539081 nacompletednot on this mapstarted 2016, after this paper: background citation

Investigating Mechanisms of Human Spinal Cord Stimulation for Purpose of Treating Restless Leg Syndrome

TypeinterventionalSponsorMarshall HollandRan2016 to 2020Enrolled15ConditionsRestless Legs Syndrome, Neuropathic PainArmsDual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement, Continuous Blood Pressure, Partial pressure of oxygen
NCT04316663 nacompletednot on this mapstarted 2020, after this paper: background citation

Well-being Promotion and Sleep Hygiene Education to Improve Sleep Quality in a Non-clinical Population of Distressed Adults Reporting Poor Sleep: A Pilot Parallel-arm, Randomized Controlled Trial

TypeinterventionalSponsorColumbia UniversityRan2020 to 2022Enrolled76ConditionsPoor Quality SleepArmsWell-Being Intervention, Sleep Hygiene
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 16 syntheses or guidelines pooled it, 602 citations in OpenAlex.

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  9. Migraine and sleep disorders: a systematic review.The journal of headache and pain · 2020
    Pooled it
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  12. Benzodiazepines for restless legs syndrome.The Cochrane database of systematic reviews · 2017
    Pooled it
  13. Opioids for restless legs syndrome.The Cochrane database of systematic reviews · 2016
    Pooled it
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  16. Rotigotine in the treatment of primary restless legs syndrome: A meta-analysis of randomized placebo-controlled trials.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015
    Pooled it
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  20. Noninvasive neuromodulation reduces symptoms of restless legs syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Trial

156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Maurice M OhayonStanford Sleep Epidemiology Research Center, Stanford University, School of Medicine, 3430 West Bayshore Road, Palo Alto, CA 94303, USA. mohayon@stanford.edu
Ruth O'Hara
Michael V Vitiello
Stanford University · USUniversity of Washington · US

Funding

Spectrum of Narcolepsy in the Probands FamiliesR01NS044199 · NINDS · STANFORD UNIVERSITY · PI OHAYON, MAURICE MOYSES · 2004 to 2007
$1.2M
NINDS NIH HHS R01 NS044199NINDS NIH HHS R01NS044199
6 · The paper itself

Abstract

Restless legs syndrome (RLS) has gained considerable attention in the recent years: nearly 50 community-based studies have been published in the last decade around the world. The development of strict diagnostic criteria in 1995 and their revision in 2003 helped to stimulate research interest on this syndrome. In community-based surveys, RLS has been studied as: 1) a symptom only, 2) a set of symptoms meeting minimal diagnostic criteria of the international restless legs syndrome study group (IRLSSG), 3) meeting minimal criteria accompanied with a specific frequency and/or severity, and 4) a differential diagnosis. In the first case, prevalence estimates in the general adult population ranged from 9.4% to 15%. In the second case, prevalence ranged from 3.9% to 14.3%. When frequency/severity is added, prevalence ranged from 2.2% to 7.9% and when differential diagnosis is applied prevalence estimates are between 1.9% and 4.6%. In all instances, RLS prevalence is higher in women than in men. It also increases with age in European and North American countries but not in Asian countries. Symptoms of anxiety and depression have been consistently associated with RLS. Overall, individuals with RLS have a poorer health than non-RLS but evidence for specific disease associations is mixed. Future epidemiological studies should focus on systematically adding frequency and severity in the definition of the syndrome in order to minimize the inclusion of cases mimicking RLS.

Indexed as

AdultAgedAge FactorsDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPregnancyPregnancy ComplicationsPrevalenceRestless Legs SyndromeSex Factors

Identifiers

PMID21795081
PMCPMC3204316
OpenAlexW2117749309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.