ArticleCancer cell international2011
A short account of metastatic bone disease.
Article in Cancer cell international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Synergistic Effects of Nutritional Formula on Joint Inflammation Through Modulation of Bone Metabolism in Rats.Nutrients · 2026Article
- Article
- Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases.International journal of molecular sciences · 2023Review
- Tumour Genetic Heterogeneity in Relation to Oral Squamous Cell Carcinoma and Anti-Cancer Treatment.International journal of environmental research and public health · 2023Review
- Biological consequences of cancer radiotherapy in the context of oral squamous cell carcinoma.Head & face medicine · 2021Review
- Heme Oxygenase-1 Is a Pivotal Modulator of Bone Turnover and Remodeling: Molecular Implications for Prostate Cancer Bone Metastasis.Antioxidants & redox signaling · 2020Article
- Biological events related to corticotomy-facilitated orthodontics.The Journal of international medical research · 2019Review
- Pain: Persistent postsurgery and bone cancer-related pain.The Journal of international medical research · 2019Review
- Spectrum of lytic lesions of the skull: a pictorial essay.Insights into imaging · 2018Review
- Molecular Pathogenesis and Diagnostic Imaging of Metastatic Jaw Tumors.Journal of pharmacy & bioallied sciences · 2017Review
- Biological Events in Periodontal Ligament and Alveolar Bone Associated with Application of Orthodontic Forces.TheScientificWorldJournal · 2015Review
- MicroRNAs in the control of metastatic bone disease.Trends in endocrinology and metabolism: TEM · 2014Review
- Dissecting the role of bone marrow stromal cells on bone metastases.BioMed research international · 2014Review
- Postoperative simple biochemical markers for prediction of bone metastases in Egyptian breast cancer patients.Ecancermedicalscience · 2013Article
- Heme oxygenase-1 (HO-1) expression in prostate cancer cells modulates the oxidative response in bone cells.PloS one · 2013Article
- MRI for the detection of prostate cancer origin vertebral metastases in the preosteoblastic phase.BMJ case reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In adults, bone is the preferential target site for metastases from primary cancers of prostate, breast, lungs and thyroid. The tendency of these cancers to metastasize to bone is determined by the anatomical distribution of the blood vessels, by the genetic profile of the cancer cells and by the biological characteristics of the bone microenvironment that favour the growth of metastatic cells of certain cancers.Metastases to bone may have either an osteolytic or an ostoblastic phenotype. The interaction in the bone microenvironment between biological factors secreted by metastatic cells, and by osteoblasts and osteoclasts, and the osteolytic and osteoblastic factors released from the organic matrix mediate a vicious cycle characterized by metastatic growth and by ongoing progressive bone destruction. This interaction determines the phenotype of the metastatic bone disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.