ArticleBMC neurology2011
Effects of light deprivation on visual evoked potentials in migraine without aura.
Article in BMC neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Exploring sensory sensitivity, cortical excitability, and habituation in episodic migraine, as a function of age and disease severity, using the pattern-reversal task.The journal of headache and pain · 2023Article
- Visual Evoked Potential Responses after Photostress in Migraine Patients and Their Correlations with Clinical Features.Journal of clinical medicine · 2021Article
- Preliminary evidence of reduced brain network activation in patients with post-traumatic migraine following concussion.Brain imaging and behavior · 2016Article
- Altered processing of sensory stimuli in patients with migraine.Nature reviews. Neurology · 2014Review
- Habituation and sensitization in primary headaches.The journal of headache and pain · 2013Review
- Lateral inhibition in visual cortex of migraine patients between attacks.The journal of headache and pain · 2013Article
- The locus of flicker adaptation in the migraine visual system: a dichoptic study.Cephalalgia : an international journal of headache · 2013Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD).
methodsWe have compared the effects of LD on VEP in migraine patients without aura between attacks (MO, n = 17) and in healthy volunteers (HV, n = 17). Six sequential blocks of 100 averaged VEP at 3.1 Hz were recorded before and after 1 hour of LD. We measured VEP P100 amplitude of the 1st block of 100 sweeps and its change over 5 sequential blocks of 100 responses.
resultsIn HV, the consequence of LD was a reduction of 1st block VEP amplitude and of the normal habituation pattern. By contrast, in MO patients, the interictal habituation deficit was not significantly modified, although 1st block VEP amplitude, already lower than in HV before LD, further decreased after LD.
conclusionsLight deprivation is thought to decrease both excitatory and subsequent inhibitory processes in visual cortex, which is in line with our findings in healthy volunteers. The VEP results in migraine patients suggest that early excitation was adequately suppressed, but not the inhibitory mechanisms occurring during long term stimulation and habituation. Accordingly, deficient intracortical inhibition is unlikely to be a primary factor in migraine pathophysiology and the habituation deficit.
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