ArticleMolecular brain2011
Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs.
Article in Molecular brain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Local Iontophoretic Application for Pharmacological Induction of Long-Term Synaptic Depression.Bio-protocol · 2025Article
- AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases.Cellular and molecular neurobiology · 2025Review
- Editorial: Regulation of AMPA Receptors, From the Genetic to the Functional Level.Frontiers in synaptic neuroscience · 2022Article
- Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD.Frontiers in synaptic neuroscience · 2022Article
- Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila.Sleep · 2020Article
- Illuminating Relationships Between the Pre- and Post-synapse.Frontiers in neural circuits · 2020Review
- Loss of DmGluRA exacerbates age-related sleep disruption and reduces lifespan.Neurobiology of aging · 2019Article
- The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents.Frontiers in pharmacology · 2019Article
- The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.Cell reports · 2018Article
- Generation of silent synapses in dentate gyrus correlates with development of alcohol addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Article
- UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Conformational signaling required for synaptic plasticity by the NMDA receptor complex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Allelic association, DNA resequencing and copy number variation at the metabotropic glutamate receptor GRM7 gene locus in bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- AMPA-silent synapses in brain development and pathology.Nature reviews. Neuroscience · 2013Review
- AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The complex actions of sumatriptan on rat dural afferents.Cephalalgia : an international journal of headache · 2012Article
- Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Molecular mechanisms involved in depotentiation and their relevance to schizophrenia.Chonnam medical journal · 2012Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
The removal of AMPA receptors from synapses is a major component of long-term depression (LTD). How this occurs, however, is still only partially understood. To investigate the trafficking of AMPA receptors in real-time we previously tagged the GluA2 subunit of AMPA receptors with ecliptic pHluorin and studied the effects of NMDA receptor activation. In the present study we have compared the effect of NMDA receptor and group I mGluR activation, using GluA2 tagged with super ecliptic pHluorin (SEP-GluA2) expressed in cultured hippocampal neurons. Surprisingly, agonists of the two receptors, which are both able to induce chemical forms of LTD, had clearly distinct effects on AMPA receptor trafficking. In agreement with our previous work we found that transient NMDA receptor activation results in an initial decrease in surface GluA2 from extrasynaptic sites followed by a delayed reduction in GluA2 from puncta (putative synapses). In contrast, transient activation of group I mGluRs, using DHPG, led to a pronounced but more delayed decrease in GluA2 from the dendritic shafts. Surprisingly, there was no average change in the fluorescence of the puncta. Examination of fluorescence at individual puncta, however, indicated that alterations did take place, with some puncta showing an increase and others a decrease in fluorescence. The effects of DHPG were, like DHPG-induced LTD, prevented by treatment with a protein tyrosine phosphatase (PTP) inhibitor. The electrophysiological correlate of the effects of DHPG in the SEP-GluA2 infected cultures was a reduction in mEPSC frequency with no change in amplitude. The implications of these findings for the initial mechanisms of expression of both NMDA receptor- and mGluR-induced LTD are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.