ArticleRespiratory research2011
Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth.
Article in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds.Cell death & disease · 2020Article
- Single-Cell Transcriptional Profiling of Cells Derived From Regenerating Alveolar Ducts.Frontiers in medicine · 2020Article
- Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration.Frontiers in bioengineering and biotechnology · 2019Review
- Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth.PloS one · 2017Article
- Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Peroxisome proliferator-activated receptor-α-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1α.The Journal of biological chemistry · 2014Article
- Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.Journal of cellular physiology · 2014Article
- Computational analysis of lung deformation after murine pneumonectomy. [corrected].Computer methods in biomechanics and biomedical engineering · 2014Article
- Laser microdissection of the alveolar duct enables single-cell genomic analysis.Frontiers in oncology · 2014Article
- Mapping cyclic stretch in the postpneumonectomy murine lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Identification of dedifferentiation and redevelopment phases during postpneumonectomy lung growth.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Migration of CD11b+ accessory cells during murine lung regeneration.Stem cell research · 2013Article
- Alveolar epithelial dynamics in postpneumonectomy lung growth.Anatomical record (Hoboken, N.J. : 2007) · 2013Article
- Mechanostructural adaptations preceding postpneumonectomy lung growth.Experimental lung research · 2012Article
- Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging.EJNMMI research · 2012Article
- Alveolar macrophage dynamics in murine lung regeneration.Journal of cellular physiology · 2012Article
- CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis.American journal of respiratory cell and molecular biology · 2012Article
- Article
- Structural and functional evidence for the scaffolding effect of alveolar blood vessels.Experimental lung researchArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
Although blood vessel growth occurs readily in the systemic bronchial circulation, angiogenesis in the pulmonary circulation is rare. Compensatory lung growth after pneumonectomy is an experimental model with presumed alveolar capillary angiogenesis. To investigate the genes participating in murine neoalveolarization, we studied the expression of angiogenesis genes in lung endothelial cells. After left pneumonectomy, the remaining right lung was examined on days 3, 6, 14 and 21 days after surgery and compared to both no surgery and sham thoracotomy controls. The lungs were enzymatically digested and CD31+ endothelial cells were isolated using flow cytometry cell sorting. The transcriptional profile of the CD31+ endothelial cells was assessed using quantitative real-time polymerase chain reaction (PCR) arrays. Focusing on 84 angiogenesis-associated genes, we identified 22 genes with greater than 4-fold regulation and significantly enhanced transcription (p <.05) within 21 days of pneumonectomy. Cluster analysis of the 22 genes indicated that changes in gene expression did not occur in a single phase, but in at least four waves of gene expression: a wave demonstrating decreased gene expression more than 3 days after pneumonectomy and 3 sequential waves of increased expression on days 6, 14, and 21 after pneumonectomy. These findings indicate that a network of gene interactions contributes to angiogenesis during compensatory lung growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.