ArticleBrain pathology (Zurich, Switzerland)2012
Genetic alterations in microRNAs in medulloblastomas.
Article in Brain pathology (Zurich, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- MicroRNAs as potential signatures of environmental exposure or effect: a systematic review.Environmental health perspectives · 2015Pooled it
- DANCR promotes glioma cell autophagy and proliferation via the miR‑33b/DLX6/ATG7 axis.Oncology reports · 2023Article
- Noncoding RNAs in pediatric brain tumors: Molecular functions and pathological implications.Molecular therapy. Nucleic acids · 2021Review
- Epigenetic-Based Therapy-A Prospective Chance for Medulloblastoma Patients' Recovery.International journal of molecular sciences · 2021Review
- miR-196B-5P and miR-200B-3P Are Differentially Expressed in Medulloblastomas of Adults and Children.Diagnostics (Basel, Switzerland) · 2020Article
- The Non-coding Side of Medulloblastoma.Frontiers in cell and developmental biology · 2020Review
- The Roles of miRNAs in Medulloblastoma: A Systematic Review.Journal of cancer prevention · 2019Review
- MicroRNA-186 suppresses lung cancer progression by targeting SIRT6.Cancer biomarkers : section A of Disease markers · 2018Article
- MicroRNA-206 inhibits the viability and migration of medulloblastoma cells by targeting LIM and SH3 protein 1.Experimental and therapeutic medicine · 2017Article
- Upregulation of kazrin F by miR-186 suppresses apoptosis but promotes epithelial-mesenchymal transition to contribute to malignancy in human cervical cancer cells.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2017Article
- miR-204 suppresses the development and progression of human glioblastoma by targeting ATF2.Oncotarget · 2016Article
- DNA Methylation mediated down-regulating of MicroRNA-33b and its role in gastric cancer.Scientific reports · 2016Article
- MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1.Diagnostic pathology · 2015Article
- MiR-22 is frequently downregulated in medulloblastomas and inhibits cell proliferation via the novel target PAPST1.Brain pathology (Zurich, Switzerland) · 2014Article
- Intratumoral heterogeneity of genomic imbalance in a case of epithelioid glioblastoma with BRAF V600E mutation.Brain pathology (Zurich, Switzerland) · 2014Article
- MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.Anti-cancer agents in medicinal chemistry · 2014Article
- Role of MYC in Medulloblastoma.Cold Spring Harbor perspectives in medicine · 2013Review
- From small to big: microRNAs as new players in medulloblastomas.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
- Downregulation of 14q32 microRNAs in Primary Human Desmoplastic Medulloblastoma.Frontiers in oncology · 2013Article
- Signaling pathway and molecular subgroups of medulloblastoma.International journal of clinical and experimental pathology · 2013Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) regulate a variety of cellular processes via the regulation of multiple target genes. We screened 48 medulloblastomas for mutation, deletion and amplification of nine miRNA genes that were selected on the basis of the presence of potential target sequences within the 3'-untranslated region of the MYCC mRNA. Differential PCR revealed deletions in miR-186 (15%), miR-135a-1 (33%), miR-548d-1 (42%), miR-548d-2 (21%) and miR-512-2 (33%) genes, whereas deletion or amplification was detected in miR-135b (23%) and miR-135a-2 (15%). In miR-33b, deletion, amplification or a mutation at the precursor miRNA were detected in 10% of medulloblastomas. Overall, 35/48 (73%) medulloblastomas had at least one alteration. Real-time RT-PCR revealed MYCC overexpression in 11 of 37 (30%) medulloblastomas, and there was a correlation between MYCC overexpression and miR-512-2 gene deletion (P = 0.0084). Antisense-based knockdown of miR-512-5p (mature sequence of miR-512-2) resulted in significant upregulation of MYCC expression in HeLa and A549 cells, while forced overexpression of miR-512-2 in medulloblastoma/PNET cell lines DAOY, UW-228-2, PFSK resulted in the downregulation of MYCC protein. Furthermore, the results of luciferase reporter assays suggested that miR-512-2 targets the MYCC gene. These results suggest that alterations in the miRNA genes may be an alternative mechanism leading to MYCC overexpression in medulloblastomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.