Evidence map›Paper›PMID 21793654›Full record

ReviewStem cells and development2012

Stem cell therapy for erectile dysfunction: a critical review.

Ching-Shwun Lin, Zhong-Cheng Xin, Zhong Wang, Chunhua Deng, Yun-Ching Huang, Guiting Lin, Tom F Lue

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Sexual Health in the Elderly Population.Current sexual health reports · 2020
    Article
  16. Review
  17. Development of nanotechnology in andrology.Translational andrology and urology · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Ching-Shwun LinDepartment of Urology, School of Medicine, University of California, San Francisco, California 94143-0738, USA. clin@urology.ucsf.edu
Zhong-Cheng Xin
Zhong Wang
Chunhua Deng
Yun-Ching Huang
Guiting Lin
Tom F Lue
University of California, San Francisco · USMemorial Hospital of South Bend · USPeking University · CNShanghai Jiao Tong University · CNSun Yat-sen University · CN

Funding

Prevention and Treatment of ImpotenceR37DK045370 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LUE, TOM F · 2004 to 2013
$3.5M
TREATMENT AND PREVENTION OF IMPOTENCER01DK045370 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI LUE, TOM F · 1994 to 2001
$631k
NIDDK NIH HHS DK045370NIDDK NIH HHS R01 DK045370NIDDK NIH HHS R37 DK045370
6 · The paper itself

Abstract

Erectile dysfunction (ED) is a prevailing health problem that seriously impacts quality of life. Current treatment options are less effective for patients having cavernous nerve (CN) injury or diabetes mellitus-related ED. These 2 types of ED are thus the main focus of past and current stem cell (SC) therapy studies. In a total of 16 studies so far, rats were exclusively used as disease models and SCs were mostly derived from bone marrow, adipose tissue, or skeletal muscle. For tracking, SCs were labeled with LacZ, green fluorescent protein, 4',6-diamidino-2-phenylindole, DiI, bromodeoxyuridine, or 5-ethynyl-2-deoxyuridine, some of which might have led to data misinterpretation. SC transplantation was done exclusively by intracavernous (IC) injection, which has been recently shown to have systemic effects. Functional assessment was done exclusively by measuring increases of IC pressure during electrostimulation of CN. Histological assessment usually focused on endothelial, smooth muscle, and CN contents in the penis. In general, favorable outcomes have been obtained in all trials so far, although whether SCs had differentiated into specific cell lineages remains controversial. Recent studies have shown that intracavernously injected SCs rapidly escaped the penis and homed into bone marrow. This could perhaps explain why intracavernously injected SCs had systemic antidiabetic effects and prolonged anti-ED effects. These hypotheses and the differentiation-versus-paracrine debate require further investigation.

Indexed as

AnimalsCell DifferentiationCell LineageClinical Trials as TopicDisease Models, AnimalElectric StimulationErectile DysfunctionFluorescent DyesGreen Fluorescent ProteinsHumansMalePenisRatsStaining and LabelingStem CellsStem Cell TransplantationFluorescent DyesGreen Fluorescent Proteins

Identifiers

PMID21793654
PMCPMC3272247
OpenAlexW2115115786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.