ArticleJournal of biomedical materials research. Part A2011
Mechanical improvements to reinforced porous silk scaffolds.
Article in Journal of biomedical materials research. Part A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Biopolymeric Insulin Membranes for Antimicrobial, Antioxidant, and Wound Healing Applications.Pharmaceutics · 2024Article
- An All-In-One Transient Theranostic Platform for Intelligent Management of Hemorrhage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- An overview of substrate stiffness guided cellular response and its applications in tissue regeneration.Bioactive materials · 2022Review
- Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels.Bioactive materials · 2021Article
- Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation.Advanced healthcare materials · 2021Article
- Chitosan/Polycyclodextrin (CHT/PCD)-Based Sponges Delivering VEGF to Enhance Angiogenesis for Bone Regeneration.Pharmaceutics · 2020Article
- Enzyme-Mediated Conjugation of Peptides to Silk Fibroin for Facile Hydrogel Functionalization.Annals of biomedical engineering · 2020Article
- Fabricating mechanically improved silk-based vascular grafts by solution control of the gel-spinning process.Biomaterials · 2020Article
- Freeze-FRESH: A 3D Printing Technique to Produce Biomaterial Scaffolds with Hierarchical Porosity.Materials (Basel, Switzerland) · 2020Article
- A multi-interpenetrating network (IPN) hydrogel with gelatin and silk fibroin.Biomaterials science · 2019Article
- Noble Metal Composite Porous Silk Fibroin Aerogel Fibers.Materials (Basel, Switzerland) · 2019Article
- Fabrication and Characterization of Chitosan-Hyaluronic Acid Scaffolds with Varying Stiffness for Glioblastoma Cell Culture.Advanced healthcare materials · 2018Article
- 3D Porous Chitosan-Alginate Scaffolds Promote Proliferation and Enrichment of Cancer Stem-Like Cells.Journal of materials chemistry. B · 2016Article
- The effect of sterilization on silk fibroin biomaterial properties.Macromolecular bioscience · 2015Article
- Transdermal delivery devices: fabrication, mechanics and drug release from silk.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Slowly degradable porous silk microfabricated scaffolds for vascularized tissue formation.Advanced functional materials · 2013Article
- Multiple silk coatings on biphasic calcium phosphate scaffolds: effect on physical and mechanical properties and in vitro osteogenic response of human mesenchymal stem cells.Biomacromolecules · 2013Article
- A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs.Biomaterials · 2012Article
- Silk constructs for delivery of musculoskeletal therapeutics.Advanced drug delivery reviews · 2012Review
- Structure and biodegradation mechanism of milled Bombyx mori silk particles.Biomacromolecules · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Load-bearing porous biodegradable scaffolds are required to engineer functional tissues such as bone. Mechanical improvements to porogen leached scaffolds prepared from silk proteins were systematically studied through the addition of silk particles in combination with silk solution concentration, exploiting interfacial compatibility between the two components. Solvent solutions of silk up to 32 w/v % were successfully prepared in hexafluoroisopropanol (HFIP) for the study. The mechanical properties of the reinforced silk scaffolds correlated to the material density and matched by a power law relationship, independent of the ratio of silk particles to matrix. These results were similar to the relationships previously shown for cancellous bone. From these data we conclude that the increased mechanical properties were due to a densification effect and not due to the inclusion of stiffer silk particles into the softer silk matrix. A continuous interface between the silk matrix and the silk particles, as well as homogeneous distribution of the silk particles within the matrix was observed. Furthermore, we note that the roughness of the pore walls was controllable by varying the ratio of the particles matrix, providing a route to control topography. The rate of proteolytic hydrolysis of the scaffolds decreased with increase in mass of silk used in the matrix and with increasing silk particle content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.