ArticleJournal of cellular physiology2011
Folic acid improves acetylcholine-induced vasoconstriction of coronary vessels isolated from hyperhomocysteinemic mice: an implication to coronary vasospasm.
Article in Journal of cellular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Myocardial infarction with non-obstructive coronary artery caused by coronary artery spasm and an increase in serum homocysteine: a case report.European heart journal. Case reports · 2025Article
- Epigenetics of Homocystinuria, Hydrogen Sulfide, and Circadian Clock Ablation in Cardiovascular-Renal Disease.Current issues in molecular biology · 2024Review
- Article
- Ability of dietary factors to affect homocysteine levels in mice: a review.Nutrition & metabolism · 2021Review
- Transient visual acuity loss after spine surgery in the prone position: a case report and literature review.The Journal of international medical research · 2020Review
- Excess Folic Acid Supplementation Before and During Pregnancy and Lactation ActivatesFrontiers in neuroscience · 2019Article
- "Boomerang Neuropathology" of Late-Onset Alzheimer's Disease is Shrouded in Harmful "BDDS": Breathing, Diet, Drinking, and Sleep During Aging.Neurotoxicity research · 2015Review
- Role of microRNA29b in blood-brain barrier dysfunction during hyperhomocysteinemia: an epigenetic mechanism.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Mitochondrial mitophagy in mesenteric artery remodeling in hyperhomocysteinemia.Physiological reports · 2014Article
- Coronary Vasospastic Angina: Current Understanding and the Role of Inflammation.Acta Cardiologica Sinica · 2013Review
- Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats.Neural regeneration research · 2012Article
- Nutrition, epigenetics, and metabolic syndrome.Antioxidants & redox signaling · 2012Review
- Folic acid improves inner ear vascularization in hyperhomocysteinemic mice.Hearing research · 2012Article
- Autophagy mechanism of right ventricular remodeling in murine model of pulmonary artery constriction.American journal of physiology. Heart and circulatory physiology · 2012Article
- Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery.Archives of physiology and biochemistry · 2011Article
- Remodeling in vein expresses arterial phenotype in hyperhomocysteinemia.International journal of physiology, pathophysiology and pharmacology · 2011Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Human atherosclerotic coronary vessels elicited vasoconstriction to acetylcholine (Ach) and revealed a phenomenon of vasospasm. Homocysteine (Hcy) levels are elevated in the atherosclerotic plaque tissue, suggesting its pathological role in endothelial damage in atherosclerotic diseases. Accordingly, we examined the role hyperhomocysteinemia in coronary endothelial dysfunction, vessel wall thickness, lumen narrowing, leading to acute/chronic coronary vasospasm. The therapeutic potential and mechanisms of folic acid (FA) using hyperhomocysteinemic cystathionine beta synthase heterozygote (CBS-/+) and wild type (CBS+/+) mice were addressed. The CBS-/+ and CBS+/+ mice were treated with or without a Hcy lowering agent FA in drinking water (0.03 g/L) for 4 weeks. The isolated mouse septum coronary artery was cannulated and pressurized at 60 mmHg. The wall thickness and lumen diameters were measured by Ion-Optic. The vessels were treated with Ach (10(-8) -10(-5) M) and, for comparison, with non-endothelial vasodilator sodium nitroprusside (10(-5) M). The endothelium-impaired arteries from CBC-/+ mice constricted in response to Ach and this vasoconstriction was mitigated with FA supplementation. The level of endothelial nitric oxide synthase (eNOS) was lower in coronary artery in CBS-/+ than of CBS+/+ mice. Treatment with FA increased the levels of Ach-induced NO generation in the coronary artery of CBS-/+ mice. The results suggest that Ach induced coronary vasoconstriction in CBS-/+ mice and this vasoconstriction was ameliorated by FA treatment. The mechanisms for the impairment of vascular function and therapeutic effects of FA may be related to the regulation of eNOS expression, NO availability and tissue homocysteine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.