Evidence map›Paper›PMID 21792729›Full record

SynthesisClinical autonomic research : official journal of the Clinical Autonomic Research Society2012

MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis.

Giorgio Treglia, Ernesto Cason, Antonella Stefanelli, Fabrizio Cocciolillo, Daniela Di Giuda, Giorgio Fagioli, Alessandro Giordano

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  4. An improved method for estimating the heart-to-mediastinum ratio from cardiac sympathetic nerve imaging with low-energy high-resolution collimators.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014
    Trial
  5. Neuroimaging in multiple system atrophy: clinical implications and novel developments.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
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  15. Article
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  17. Article
  18. Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  19. Optimal Protocol and Clinical Usefulness ofNuclear medicine and molecular imaging · 2023
    Article
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giorgio TregliaInstitute of Nuclear Medicine, Policlinico Gemelli, Catholic University of the Sacred Heart, Rome, Italy. giorgiomednuc@libero.it
Ernesto Cason
Antonella Stefanelli
Fabrizio Cocciolillo
Daniela Di Giuda
Giorgio Fagioli
Alessandro Giordano

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDifferential diagnosis between Parkinson's disease (PD) and other Parkinsonism using clinical criteria or imaging methods is often difficult. The purpose of this study is to systematically review and meta-analyze published data about the diagnostic performance of myocardial innervation imaging using (123)I-metaiodobenzylguanidine (MIBG) scintigraphy in differential diagnosis between PD and other Parkinsonism.

methodsA comprehensive computer literature search of studies published through March 2011 regarding MIBG scintigraphy in patients with PD and other Parkinsonism was performed in PubMed/MEDLINE and Embase databases. Only studies in which MIBG scintigraphy was performed for differential diagnosis between PD and other Parkinsonism were selected. Pooled sensitivity, pooled specificity and area under the ROC curve were calculated to measure the accuracy of MIBG scintigraphy in differential diagnosis between PD and other Parkinsonism.

resultsNineteen studies comprising 1,972 patients (1,076 patients with PD, 117 patients with other Lewy body diseases and 779 patients with other diseases) were included in this meta-analysis. The pooled sensitivity of MIBG scintigraphy in detecting PD was 88% (95% CI 86-90%); the pooled specificity of MIBG scintigraphy in discriminating between PD and other Parkinsonism was 85% (95% CI 81-88%). The area under the ROC curve was 0.93.

conclusionsIn patients with clinically suspected PD, myocardial innervation imaging demonstrated high sensitivity and specificity. MIBG scintigraphy is an accurate test in this setting. Nevertheless, possible causes of false-negative and false-positive results should be kept in mind when interpreting the scintigraphic results.

Indexed as

3-IodobenzylguanidineRadiopharmaceuticalsDiagnosis, DifferentialFalse Negative ReactionsFalse Positive ReactionsHeartHumansLewy Body DiseaseParkinson DiseaseParkinsonian DisordersRadionuclide ImagingReproducibility of ResultsROC Curve3-IodobenzylguanidineRadiopharmaceuticals

Identifiers

PMID21792729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.