ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2012
Systemic and cerebral hemodynamics during cognitive testing.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03602014 (Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Targeting inflammation to influence cognitive function following spinal cord injury: a randomized clinical trial.Spinal cord · 2017Trial
- Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls.Physiological reports · 2016Trial
- Orthostatic responses to anticholinesterase inhibition in spinal cord injury.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Trial
- Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- Altered functional connectivity underpins cognitive changes in chronic spinal cord injury.Brain communications · 2026Article
- Article
- Cognitive, behavioral and psychiatric symptoms in patients with spinal cord injury: a scoping review.Frontiers in psychiatry · 2024Article
- Multidimensional review of cognitive impairment after spinal cord injury.Acta neurologica Belgica · 2021Review
- Heart rate and blood pressure response improve the prediction of orthostatic cardiovascular dysregulation in persons with chronic spinal cord injury.Physiological reports · 2020Article
- The impact of level of injury on patterns of cognitive dysfunction in individuals with spinal cord injury.The journal of spinal cord medicine · 2020Article
- Patterns of cognitive deficits in persons with spinal cord injury as compared with both age-matched and older individuals without spinal cord injury.The journal of spinal cord medicine · 2020Article
- A Community Perspective on Bowel Management and Quality of Life after Spinal Cord Injury: The Influence of Autonomic Dysreflexia.Journal of neurotrauma · 2018Article
- Alterations in autonomic cerebrovascular control after spinal cord injury.Autonomic neuroscience : basic & clinical · 2018Review
- Inter-day reliability of blood pressure and cerebral blood flow velocities in persons with spinal cord injury and intact controls.The journal of spinal cord medicine · 2017Article
- Dynamic wheelchair seating positions impact cardiovascular function after spinal cord injury.PloS one · 2017Article
- A cerebral blood flow evaluation during cognitive tasks following a cervical spinal cord injury: a case study using transcranial Doppler recordings.Cognitive neurodynamics · 2015Article
- Prevalence of abnormal systemic hemodynamics in veterans with and without spinal cord injury.Archives of physical medicine and rehabilitation · 2015Observational
- Decentralized cardiovascular autonomic control and cognitive deficits in persons with spinal cord injury.The journal of spinal cord medicine · 2013Review
- 31st g. Heiner sell lectureship: secondary medical consequences of spinal cord injury.Topics in spinal cord injury rehabilitation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCognitive deficits are reported in 10-60% of individuals with SCI, the primary etiology of these deficits is believed to be concomitant traumatic brain injury (TBI). We recently documented diminished memory and marginally deficient attention and processing speed in individuals with SCI discordant for hypotension but matched for TBI.
methodsTwenty-nine individuals participated: 16 non-SCI controls, 6 paraplegic (T2-T10) and 7 tetraplegic (C4-C8). The Stroop test was used to measure cognitive function and transcranial Doppler ultrasound was used to measure cerebral blood flow (CBF) while resting (5 min) and continuously during cognitive testing. Mean arterial pressure (MAP) was calculated from three brachial blood pressures and cerebral vascular resistance index was calculated as: CVRi = MAP/CBF.
resultsThe paraplegia group (54 ± 6) was marginally older than the non-SCI (42 ± 15; p = 0.06) and tetraplegic (42 ± 11; p = 0.09) groups. Compared to non-SCI group, normalized t-score on the Stroop Color (SC) task was significantly lower in the paraplegic group (p < 0.05). In the tetraplegic group, MAP was significantly lower (p < 0.05) than the non-SCI and paraplegic groups, and related to SC t-score (r (2) = 0.873; p < 0.01). In the paraplegic group, CBF was reduced (p < 0.05) and CVRi increased (p < 0.05) compared to the non-SCI group, and CVRi was increased compared to the tetraplegic group (p < 0.05). A significant inverse relationship was noted between change in CVRi and SC t-score in the non-SCI group.
conclusionAsymptomatic hypotension relates to cognitive performance in persons with tetraplegia; therefore, BP normalization should be considered. The inappropriate cerebral vascular response to cognitive testing and poor test performance should be investigated in persons with paraplegia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.